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1987 Fiscal Year Final Research Report Summary

Quantitative Analyses of the Atherosclerotic aorta in Watanabe Hereditary Hyperlipidemic(WHHL) Rabbits.

Research Project

Project/Area Number 60480238
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionNational Cardiovascular Center

Principal Investigator

HASEGAWA Masamitsu  National Cardiovascular Center Research Institute, Chairman, 研究部, 部長 (30020738)

Co-Investigator(Kenkyū-buntansha) WATANABE Yoshio  Kobe University, School of Medicine, Associate Professor, 医学部, 助教授 (00031401)
Project Period (FY) 1985 – 1987
KeywordsAtherosclerosis / Pressure pulse wave / WHHL rabbit / Atheromatous plaque / Wall thickness / Stress-strain curve / 弾性率
Research Abstract

Our project was aimed to obtain informations necessary to understand the severity of atherosclerosis quantitatively. For this purpose, we analyzed the pressure pulse waves along the aorta in inherited hyperlipidemic(WHHL) rabbits with different ages with special reference to rheological properties and morphological features of the aortic walls. Methods: After intravenous injection of pentobarbital(25mg/ml), a microtip pressure transducer was placed into the aortic arch through the left carotid artery. Another transducer was inserted into the right femoral artery and advanced to the abdominal aorta and then to the thoracic aorta. Pressure pulse waves were simultaneously determined at two microtip sites. Longitudinal and circumferential strips 5mm wide were made from the excised thoracic aorta and were subjected to the stress-strain test. On the other hand, the area of atheromatous plaques attached on the intimal surface was measured at five aortic portions by means of an area computing … More device.
Results and Discussions: Pressure pulse waves at each aortic portion showed an increase in amplitude of the percussion wave with advancing age, followed by a gradual disappearance of dicrotic notches and dicrotic waves. A positive relationship was found between the wall thickness and the the month of age with the correlation coefficient of 0.66(p<0.01). Elastic moduli at the stresses of 5x10^5 and 10^6dyn/cm^2 calculated from the stress-strain curve increased significantly with advancing age in the longitudinal and circumferential strips. Therefore, age-related changes in the pressure pulse waves were closely related to the increased wall thickness in addition to the increased elastic modulus due to the compositional changes in the wall. The earliest atheromatous plaques appeared in the aortic arch of WHHL rabbits aged two months. Early lesions were located at the origin of aortic branches with specific anatiomical sites and shapes indicating the rheological contribution of the local blood flow properties to the early atherogenesis in the aorta. Less

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 長谷川正光: 日本レオロジー学会誌. 13. 178-183 (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 長谷川正光: 日本バイオルオロジー学会論文集. 9. 295-298 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 長谷川正光: 第35回レオロジー討論会講演要旨集. 141-144 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa, M.: Biorheology. 24. 512 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa, M.: J. Physiol. Soc. Japan. 49. 523 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa, M.: Biorheology.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuchiya, M.: "Microcirculation-an update, Vol. 1" Excerpta Medica, 792 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa, H: "Rheological Properties of Atherosclerotic Aorta," J. Soc. Rheol. Japan. 13. 178-183 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hasegawa, M.: "Morphological and Structural Analysis of Atherosclerotic Aortic Walls." Proc. Jap. Soc. Biorheol.9. 295-298 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hasegawa, M.: "Static Viscoelasticities and Wall Structures of Atherosclerotic Thoracic Aortas." Proc. 35th Rheology Conference. 141-144 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hasegawa, M.: "Morphological Features of Early Atherosclerotic Lesions in the Aorta from WHHL rabbits." Biorheology. 24. 512- (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hasegawa, M: "Rheological Properties of the Thoracic Aorta in Normal and WHHL Rabbits." Biorheology.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuchiya, M.: Excerpta Medica. Microcirculation - an update, Vol.1, 792 (1987)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1989-03-30  

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