1987 Fiscal Year Final Research Report Summary
Experimental Study on Peripheral Hemodynamics in Chronic Peripheral Arterial Occlusive Diseases in Reference to Non Surgical
| Project/Area Number |
60480292
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Okayama University |
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Principal Investigator |
KOMOTO Yoshiaki Inst Envi Med, Okayama Univ Med Schl Prof, 医学部附属環境病態研究施設, 教授 (20033160)
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| Co-Investigator(Kenkyū-buntansha) |
SUNAKAWA Mitsuru Misasa Hosp, Okayama Univ. Hosp. Assist Prof., 三朝分院, 助手 (30163041)
NAKAO Toshihiko Inst Envi Med, Okayama Univ Med Schl Assist Prof., 助手 (80198027)
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| Project Period (FY) |
1985 – 1987
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| Keywords | Tissue perfusion / Ischemic limbs / Walking exercise / Mass specttometry / Partial pressure of tissue gas / Non surgical treatment / PGE_1 / Claudication |
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| Research Abstract |
Improvements in limb tissue perfusion following surgically induced ischemia in dogs were experimentally evaluated to clarify the improvement in hemodynamics following walking exercise in chronic, peripheral arterial occlusive diseases (ischemic limbs). Assisted by an on-line computer system with medical mass spectrometry, local tissue perfusion rate was calculated on the basis of the clearance curve of tissue pCO_2 following electrical stimuli that simulated exercise in the ischemic legs. Local tissue perfusion rate improved in ml/100g/min from 9.51 to 12.41 in one month, 14.59 in three months, 15.11 in six months and 17.19 at twelve months (17.75 in control group).
No significant increase in the perfusion rate was found between the groups with and without lumbar sympathetic ganglionectomy. Local tissue perfusion rate was found increased with the application of PGE_1 ; 14.11 at one month, 16.48 at 3 months and 19.13 at 6 months.
The improvement of ischemic symptoms with continued exercise and/or with PGE_1 is attributed to improvements in tissue perfusion or in collateral circulation, non surgical treatments based on the natural history of chronic peripheral arterial occlusive disease, particularly intermittent claudication, appear feasible.
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[Publications] Komoto,Y.,Nakao,T.,Sunakawa,M.Yorozu,H.: "Oxygen Transport to Tissue X,(p634-645)ed.M.Mochizuki,C.R.Honig,T.Koyama,T.K.Goldstick,and D.F.Bruley" Plenum Publishing Corporation,New York & London, 766 (1988)
Description
「研究成果報告書概要(和文)」より
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[Publications] Komoto, Y., Nakao,T., Sunakawa,M., Yorozu,H.: "Elevation of tissue pO_2 with improvement of tissue perfusion by topically applied CO_2." Oxygen transport to tissue X,ed. M.Mochizuki, C.R.Honig, T.Koyama, T.K.Goldstick, and D.F.Bruley Plenum Publishing Corp. New York & London. 637-645 (1988)
Description
「研究成果報告書概要(欧文)」より
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