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1987 Fiscal Year Final Research Report Summary

Mechanism of Anticancer Activity of Steroidal Compound

Research Project

Project/Area Number 60480373
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

OKADA Hiroji  Professor of Kyoto Prefectural University of Medicine, 医学部, 教授 (60079861)

Project Period (FY) 1985 – 1987
KeywordsProgestogen / Anticancer activity / Endometrial cancer
Research Abstract

For the treatment of endometrial cancer with extensive regions, progestational compounds are usually used. It is not conclusive, hoerver, that the progestational comound exert its effect via progesterone receptor, since we have demonstrated that some steroid sensitivities which is found in normal endometrial tissue is lost or decreasd in cancer tissue.Induction of peroxidase activity by estrogen and that of estradiol dehydrogenase activity by progestogen are the examples. The antitumor activities of steroid compounds on endometrial cancer were examined in vitro by human tumor clonogenic assay. Clinically effective compounds including medroxyprogesteorne acetate and 17<alpha>- hoydroxyprgesterone caproate were effective. Howerver several potent progestational compounds including norethindrone were ineffective in this in vitro system. Norethindrone and RU486, a progesterone antagonist, both had no influence on the effect of medroxyprogesterone acetate. These results indicated that the anti-tumor activity of medroxyprogesterone acetate did not proceed via the so-called progesterone receptor. We demonstrated two types of medroxyprogesterone actate binding component in normal endometrialand cancer tissue. One is identical with the so-called progesterone receptor and the othere has low affinity, high capacity binding property.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] 岡田弘二 指導, 北脇城: 日本内分泌学会雑誌. 63(7). 894-912 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤田宏行, 藤本次良, 岡田弘二: 産婦人科の進歩. 39(4). 615-616 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡田弘二: 図説臨床(癌)シリーズ. 12. 153-159 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡田弘二, 中田好則, 藤本次郎, 藤田宏行: 癌と化学療法. 14(10). 2837-2844 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡田弘二: Oncology and Chemotherapy. 4. (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroji, Okada: "Chemotherapy and Endocrine Therapy of Endometrial Cancer" Progress in Cancer Clinics. No.12. 153-159 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroji, Okada: "Hormone Dependency and Progestogen Therapy in the Treatment of Endometrial Cancer" Japanese Journal of Cancer and Chemotherapy. 14. 2837-2844 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Jiro, Fujimoto: "Progestogen Therapy of Endometrial Cancer---Mechanism of Action---" Advances in Obstetrics and Gynecology. 39. 615-616 (1987)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1989-03-30  

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