1987 Fiscal Year Final Research Report Summary
Study on multiphase biomedical materials compatible with bone tisse in oral surgery
| Project/Area Number |
60480441
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
外科・放射線系歯学
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| Research Institution | Kanagawa Dental Collage |
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Principal Investigator |
SHIMURA Kaizo Kanagawa Dental Collage, 歯学部, 教授 (20084725)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Shinichiro Kanagawa Dental Collage, 歯学部, 助手 (90170323)
KINOSHITA Yukihiko Kanagawa Dental Collage, 歯学部, 助教授 (70084770)
MASUHARA Eiichi Japane Institute of Advanced Dentistry, 名誉教授 (00013772)
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| Project Period (FY) |
1985 – 1987
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| Keywords | Multiphase biomedical material / Compatibility with bone / Dental implant / Artificial bone / Composite material / Hydroxyapatite / Fluoropolymer / フッ素系高分子 |
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| Research Abstract |
We have developed a multiphase material consisting of hydroxyapatite [HAP],poly(2,2,2-trifluoroethyl metacrylate)[PTFEMA],and a metal core for use as a dental implant and bone substitute .
Our studies showed that,(1) HAP-PTFEMA composite materials containing 70 wt% of HAP particles have approximately the same elasticity as bone ,and these composite materials bonded to an inner metal core have great strength and toughness . (2) These materials showed no cytotoxity,litlle tissue irritation , and good bone-tissue affinity ( direct bonding with bone ) .
On the basis of these test results, we have developed a dental implant and a bone substitute for mandibular reconstruction .
Our studies indicate that,(3) the dental implant, the surface of which consistes of this composite material bonded to a titanium tube having stress breaking structures in its inner space, showed biological mobility, good stress dispersion and shock absorption when subjected to computer analysis .
(4) The artificial bone constructed of this mutiphas material was easily processed and manipulated,and
(5)its clinical application yielded good results .
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