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1987 Fiscal Year Final Research Report Summary

Studies on the Preseut state of Laboratory Animal Allergy in Japan and its Preventive measures

Research Project

Project/Area Number 60480486
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Laboratory animal science
Research InstitutionKagoshima,University

Principal Investigator

CHUHEI Yamauchi  Faculty of Medicine, kagoshima University ; Associate Professor, 医学部, 助教授 (00041377)

Co-Investigator(Kenkyū-buntansha) TOMOYUKI Ueda  Faculty of Medicine, kagoshima University ; Asistant, 医学部, 助手 (80160175)
KOREBUMI Minakami  School of Allied Medical Science, kagoshima University; Associate Professor, 医療技術短期大学部, 助教授 (80041325)
SHINICHI Nozoe  Faculty of Medicine, kagoshima University ; Associate Professor, 医学部, 助教授 (10117533)
TAKUO Nobori  Medical Hospital, Kagoshimo University; Lecturer, 医学部付属病院, 講師 (40094164)
TOSHIO Matsushita  Faculty of Medicine, kagoshima University ; Professor, 医学部, 教授 (10022790)
Project Period (FY) 1985 – 1987
KeywordsLaboratory animal / Allergy / Allergen / Animal room / Dust particle / 空調
Research Abstract

Among 5,641 Persons in laboratory animal facilities of 137 research institutes, 1,304(23%) had one or more allergic symptoms associated with laboratory animals(LAA). Of allected individuals, 78% had nasal, 46% skin, 43% eye, 34% pulmonary symptoms. High incidence of LAA was found in the group of subjects who had daily contact with laboratory animals. The subjects of 70% developed LAA symptoms within three years of exposure. The individial which had the family history of allergy and with a history of previous allergy tended to developed LAA.
The positive rate of some sensitive subjects to guinea-pigs by skin test using extracted substances were 100% for urine, 83% for epithelium and saliva and 67% for serum prepared from guinea-pigs. Urine antigen was protein of low molecular weight, and a part of this antigen was common to that of epithelium, saliva, and serum. The levels of total igE and RAST in the subjects tended to high than that of non-sensitive control group.
In the animal room equiped with conventional turbulent flow air conditioning system, most of the protein was contained in dust particules over 1 <mu>m in size. For keeping air cleanliness in the working area of the animal room, we have developed a one-way flow air conditioning system in which the air flows the working area of the animal room through the rack and cages to exhaust side. The particle level in the working area of an animal room of turbulent flow system reached about class 10,000, however, the level of added sliding doors or curtains in front of the rack in the one-way-flow room was maintainedat class 100 with almost no dust particles over 1<mu> in size, except cage changing. Therefore, the wokers should be to wear a facemask when they work in animal room.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] 実験動物アレルギー研究班山内忠平 他: 実験動物. 36. 30-36 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山内忠平: 実験動物. 35. 537-544 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山内忠平: ラボラトリーアニマル. 4. 45-49 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 水上惟文: 実験動物. 35. 293-297 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 水上惟文: 実験動物. 36. 431-434 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小原徹: 実験動物. 35. 357-361 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山内忠平: "実験動物の環境と管理第2版" 出版科学, 239 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Study group on the prsent state of laboratory animal allergy and its countermeasures.(Representative C. YAMAUCHI).: "The survey of laboratory animal allergy in Japan." Experimental Animals. 36. 95-101 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C,YAMAUCHI, T,OBARA, N,FUKUYAMA, T,UEDA, D,ENOKITA and S,YANAGIMOTO.: "One-way air current system from air supply to exhaust air in laboratory animal room." Experimental Animals. 35. 537-544 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C,YAMAUCHI: "Laboratory animal allergy and its preventive measures." Animal Experiments and Laboratory Animals.4. 45-49 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K,MINAKAMI, T,OBARA and C,YAMUCHI.: "Filter efficiency of commercial face masks of particles and airborne bacteria" Experimental Animals. 35. 293-297 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K,MINAKAMI, C,YAMAUCHI and T,HANADA.: "Airborne dust and its protein in laboratory animal facilities." Experimental Animals. 36. 431-434 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] C,YAMAUCHI: Shutsupan Kagaku Co., Tokyo. Environmental Control of Laboratory Animals, 2nd ed., 239 (1986)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1989-03-30  

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