1986 Fiscal Year Final Research Report Summary
Studies on experimentally-induced acute hepatic failure
| Project/Area Number |
60570335
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Osaka City University |
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Principal Investigator |
SAITO Shinobu Osaka City University Medical School, 医学部, 助手 (60162202)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGAMI Yoshihide Osaka City University Medical School, 医学部, 助手 (40178546)
MIZOGUCHI Yasuhiro Osaka City University Medical School, 医学部, 講師 (00094491)
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| Project Period (FY) |
1985 – 1986
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| Keywords | acute hepatic failure / fulminant hepatitis / macrophage / hepatocytotoxic factor / 肝不全 |
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| Research Abstract |
When heat-killed Propionibacterium acnes (P. acnes) is intravenously injected into mice and seven days later, a small amount of gram-negative lipopolysaccharide (LPS) is also intravenously injected, most of the mice die of massive necrosis. In this experimentally-induced acute hepatic failure, the adherent cells accumulated into the liver are primed by P. acnes and activated by LPS, producing the cytotoxic factor. This hepatocytotoxic factor is a protein-like substance and is relatively unstable to heat. Furthermore, in this experimentally-induced acute hepatic failure model, gomisin A, AA861, azelastine and prostaglandin <E_1> remarkably increase the survival rate of mice and improve the histological changes and necrosis of the liver cells.
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[Publications] Tsutsui H, Mizoguchi Y, Miyajima K, Sakagami Y, Higashimori T, Seki S, Yamamoto S, Hara H, Tatsumi Y, Monna T, Morisawa S.: "Studies on the hepatocellular injury in an experimentally-induced acute hepatic failure. I. Possible involvement of activated adherent cells." Jpn J Gastroenterol. 82. 603-609 (1985)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Tsutsui H, Mizoguchi Y, Miyajima K, Arai T, Higashimori T, Seki S, Yamamoto S, Hara H, Tatsumi Y, Kinoshita H, Morisawa S.: "Studies on the hepatocellular injury in an experimentally-induced acute hepatic failure. II. Changes in spleen cells and peritoneal macrophage functions." Jpn J Gastroenterol. 82. 1520-1526 (1985)
Description
「研究成果報告書概要(欧文)」より
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