1987 Fiscal Year Final Research Report Summary
Effect of high frequency positive pressure ventilation on hypoxic pulmonary vasoconstriction
| Project/Area Number |
60570730
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | Kitasato University |
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Principal Investigator |
WATANABE Satoshi Associate Professor Deparetment of Anesthesiology Kitasato University School of Medicine, 医学部, 助教授 (40050463)
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| Co-Investigator(Kenkyū-buntansha) |
SUGAYA Kazue Assistant Deparetment of Anesthesiology Kitasato University School of Medicine, 医学部, 助手 (90179119)
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| Project Period (FY) |
1985 – 1987
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| Keywords | High frequency positive pressure ventilation / 低酸素性肺血管収縮反応 |
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| Research Abstract |
The effects of high frequency positive pressure ventilation on hypoxic pulmonary vasoconstriction was investigated in dogs, ventilated via modified Carlen's double lumen endotracheal tube. I. Closed-chest experiments ; A-group:Right lung was ventilated with oxygen and left lung with nitrogen,using conventional mechanical ventilator. B-group:In A-group. high frequency positive pressure ventilation of 10 Hz was superimposed in left lung. C-group:Right lung was ventilated with oxygen, using conventional mechanical ventilator and left lung was ventilated with nitrogen, using high frequency positive pressure ventilator(10 Hz). P a_<o2> of A-group fell to 92.8mmHg at 30 minutes, then rose to 161.6mmHg at 120 minutes. This change was statistically significant. P a_<o2> of A- & B-group did not show statistically any changes. Mean pulmonary arterial pressure had a tendency to rese slightly, but this was not statisticall significant.
II. Open-chest experiments ; Electromagnetic flow probe was implanted on pulmonary artery of lung ventilated with nitrogen, using high frequency positive pressure ventilator(10 Hz). The other lung was ventilated with oxygen, using conventional mechanical ventilator.
P a_<o2> change was similar to C-group in closed-chest dogs. Pulmonary blood flow of hypoxic lung fell to about 70% at 30 minutes and did not changed throughout experiments. These results suggests that high frequency positive pressure ventilation(10 Hz) attenuates hypoxic pulmonary vasoconstriction.
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Research Products
(1 results)
