| Co-Investigator(Kenkyū-buntansha) |
NAKAJIMA Toshifumi Department of Radiology, Osaka City University Medical School, 医学部, 助手 (30155725)
KONISHI Kazuo Department of Otolaryngology, Osaka City University Medical School, 医学部, 助手 (50145801)
MORISAKI Noboru Department of Otolaryngology, Osaka City University Medical School, 医学部, 助手 (00166399)
CHO Kansei Department of Otolaryngology, Osaka City University Medical School, 医学部, 講師 (60128741)
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| Research Abstract |
Patients with cancer of the head and neck received irradiation and chemotherapy before operation. Postoperatively, they were treated with interferon <alpha> (IFN- <alpha> ) and OK-432, an immunopotentiator, for the prevention of tumor recurrence. The synthesis of IFN- <gamma> , which is induced by OK-432, was enhanced by the combined use of OK-432 and IFN- <alpha> . Furthermore, Long-term follow-up demonstrated that the tumor recurred with significantly lower frequency in the treated group than in the untreated group. (Arch Oto-rhinolaryngol 243:281-287, 1986). By this combined treatment, peripheral blood NK activity was increased, interleukin 2 receptor positive cells were mobilized, and leukopenia was prevented. (Immunopharmacological aspects of OK-432 in humans Excepta Medica P161-173, 1986). Consequently, it was hypothesized that tumor recurrence might be prevented through these mechanisms. In order to look into the possibility of this treatment not only as a countermeasure against
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tecurrence but also as a curative means, the following study was undertaken: Severe cases of recurred cancer of the head and neck and unoperated cases having a metastatic lesion in a distant organ were treated locally by hyperthermia with irradiation and systemically by chemotherapy. In addition, they received IFN- <alpha> and OK-432 for preventing leukopenia and reduction in immunocapacity due to irradiation and chemotherapy. In an in vitro system using cultured tumor cells of an established cell line derived from maxillary carcinoma, phase S was prolonged by irradiation and cells whose proliferation was suppressed by irradiation were killed by heat treatment (42゜C or 43゜C). (Progress in hyperthermic oncology, Shinohara shupan P72-73, 1986). This hyperthermia exerted the same effect on radioresistant cells (maxillary carcinoma-derived cells which acquired the ability to survive 10 Gy irradiation consequently upon repetitive exposure to radioactive rays). Clinically, cervical lymphnode metastasis was subjected to irradiation and hyperthermia. This combined treatment was more effective than irradiation alone against a lesion of not less than 5 cm in size. Less
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