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1987 Fiscal Year Final Research Report Summary

Mathematical Model of Arrhythmia Generating mechanism Besed on the Modulated Parasystole Theory

Research Project

Project/Area Number 60870087
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field 医学一般
Research InstitutionUniversity of Tokyo

Principal Investigator

IKEDA Kenji  Faculty of Medicine, University of Tokyo, 医学部, 助手 (70010030)

Co-Investigator(Kenkyū-buntansha) AOKI Takao  Faculty of Medicine, University of Tokyo, 医学部, 文部技官 (00101113)
TANAKA Hiroshi  Hamamatsu University School of Medicine, 医療情報部, 助教授 (60155158)
FURUKAWA Toshiyuki  Research Center for Advanced Science and Technology, University of Tokyo, 先端科学技術研究センター, 教授 (20101082)
Project Period (FY) 1985 – 1987
Keywordsmathematical model of arrhymia / non-linear synchronization theory / ectopic excitation genration / finite element method / 逆問題解法 / 心房 / 心室センシング
Research Abstract

A mathematical model of the cardiac conduction system has been developed in order to clarify the mechanisms of cardiac arrhythmia. The model is consist of the network of elements which simulate the conductivity chatacteristics of the heart muscle scintidium, where each element is defines by a unique set of time parameters from the action potential. The mathematical desctiption is separated from the network structure, and defined ad a non-linear synchronization theory, thus making is possible to rum the model with different network sizes, and to apply the finite element method for precise modeling. In addition, id became possible to construct together an a prio'ri knowledge about the relationship between cardiac cell metabolism and ion channel function. The details of the model consist of three parts, i.e., impulse progaration, ectopic excitation generation mechanism and electopotential generation. In the inverse solution approach, the arrival time disteibution of excitation front within cardiac scintidium cell structure were calculated from the data of body surface potential distributions. Referring to the conduction process model, the parameters is estimated from the above same data. Conclusively, it is believable that modeling of the different mechanisms which cause cardiac arrhythmias is an important area and that the model has been shown to be useful not only for basic understaunding of cardiac electric physiology, but also for the savelopment of frontier technology of an automated atthythmia recognition and a simultaneous defibrillation treatment, for an example, the improvement of atrioventriculat sensing monitor.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 田中博,秋場優子,仲村洋之,伊原正,原正一郎,中沢真也,青木隆夫,古川俊之 他: 医用電子と生体工学. 22. 248-249 (1984)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ahlfeldt; H.Tanaka; M-E Nygards & O. Wigertz: Computer in Cardiology. (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 古川俊之,田中 博: 病態生理. 5. 355-362 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ahlfeldt; H.Tanaka; M-E Nygards; T.Furukawa & O. W.Gertz: Computer and Biomedical Research. 20. 305-323 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Ahlfeldt; H.Tanaka; M-E Nygards; & T. Furukawa: Pacing and Clinical Electrophysiology.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. Tanaka, Y.Akiba, K.Hirayanagi, H.Nakamura. T.Ihara, S.Hara, S.Nakazawa 7 S.Kinoshita, T.Aoki, N.Yamnoi & T. Furukawa: "Mathematical Model of Arraththmia Genetating mechanism Based on the Modulated parasystole Theory" Japanese Journal of Medical Electronics and Biological Engineering. 22. 248-249 (1984)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Shlgeldt, H.Tanaka, M-E Nygards & O. Wigarts: "A mathematical mode of the cardial consuction system including external pacemakers" Computer is Gardiology(IEEE Computer Society). (1985)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Furukawa & H. Tanaka: "Two Dimensional Network Model of Paroxysmal Tachycatdia" Medicina Philosophica. 5. 355-362 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ahifeldt. H. Tanaka, M-E Nygards, T. Furukawa & O. Wigertz: "Computer Simulation of Cardiac Arrhythmias" 20. 305-362 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Ahlfeldt, H. Tanaka, M-E Nygards, & T. Furukawa: "Computer Simulation of Cardial Pacing" Pacing and Clinical Electrophysiology.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1989-03-30  

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