1987 Fiscal Year Final Research Report Summary
Synthesis and Evaluation of Photosensitizeing Dyes for Photodynamic Diagnosis and Therapy.
| Project/Area Number |
60890007
|
|---|
| Research Category |
Grant-in-Aid for Developmental Scientific Research
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
広領域
|
|---|
| Research Institution | Technological University of Nagaoka |
|---|
Principal Investigator |
OGOSHI Hisanobu Professor of Technological University of Nagaoka, 工学部, 教授 (90026188)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YAMASHITA Mikio Chief Researcher of Electrotechnical Laboratory, 主任研究官
AOYAGI Katsuhiro Assitant Professor of Fukushima National College of Technology, 講師 (40150940)
MIYAKE Hitoshi Associate Professor of Techcnological University of Nagaoka, 工学部, 助教授 (10143819)
KATO Harunobu Assitant Professor of Tokyo Medical College, 医学部, 講師 (20074768)
AIZAWA Kastuo Associate Professor of Tokyo Medical College, 医学部, 助教授 (40074645)
|
|---|
| Project Period (FY) |
1985 – 1987
|
| Keywords | EARLY CANCER / PHOTODYNAMIC DIAGNOSIS AND THERAPY / PHOTOSENSTITIZIND DYES / パルス色素レーザー |
|---|
| Research Abstract |
Varous Kinds of Porphyrin and cholorophyll derivatives have been synthesized from naturally occuring protoporphyrins and chloorphyll and stepwise synthetic methods to provide new photosensitizing dyes in photodynamic diagnosis and therapy in early cancer. Specific accumu- lation of dyes in cancer cell depends upon their molecular structure; highly symmetric allocation of polar substituents shows no effective accumulation of dye in cancer cell; localized substitutuion of both polar and non-polar groups is essential to exert diagnosis. Mechanism of interaction between dye and cancer cell has been elucidated; dye molecule injected in blood binds membrene of cancer cell, penetrates the membrene, contact with the membrene of mitochondria. Fluorine containning dyes seem to be promisible chemical probe to three dimensional analysis of deep cancer with nuclear magnetic resonance technique.
|
