1987 Fiscal Year Final Research Report Summary
Strcture Formation of Biological Membranes
| Project/Area Number |
61302085
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
生物物性学
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
MITAKU Shigeki Tokyo University of Agriculture and Technology, 工学部, 助教授 (10107542)
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| Co-Investigator(Kenkyū-buntansha) |
KAWATO Suguru The University of Tokyo, 教養学部, 助教授 (50169736)
AKUTSU Hideo Yokohama National University, 工学部, 助教授 (60029965)
KINOSITA Kazuhiko The Institute of Physical and Chemical Research, 研究員 (30124366)
KASAI Michiki Ohsaka University, 基礎工学部, 教授 (40022595)
KIRINO Yutaka Kyushu University, 薬学部, 教授 (10012668)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Biological membrane / Lipid bilayer / Membrane protein / Intramolecular / interaction / Structure formation / Higer order structure |
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| Research Abstract |
biological membrane is comprised of various kinds of proteins and lipids. However, its structure appears simple, in which lipid bilayer forms the matrix and membrane proteins are embedded in it. The purpose of this project is to investigate the mechanism of the higher order structure of biological membranes from five points of view: (1) Static structure of membrane and lipid bilayer, (2) dynamic structure of membrane, (3) Intramembrane interaction associated with ordered structures, (4) relationship between the structure and the function of membrane proteins, and (5) new techniques studying biological membranes. The results of studies revealed that ordered structures are formed by the balance of electrostatic interaction, hydrogen bonds and hydeophobic interaction and that each interaction plays different role in the ordering phenomena of membrane.
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