1988 Fiscal Year Final Research Report Summary
Surface Structure of Bioactive Ceramics
| Project/Area Number |
61470072
|
|---|
| Research Category |
Grant-in-Aid for General Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
無機工業化学
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
KOKUBO Tadashi Institute for Chemical Research. Kyoto University, 化学研究所, 教授 (30027049)
|
|---|
| Project Period (FY) |
1986 – 1988
|
| Keywords | Bioactivity / Ceramics / Bonding to bone / Artificial bone / Apatite / FT-IR |
|---|
| Research Abstract |
In order to reveal factors governing bioactivity of ceramics, surface structural changes due to exposure to a simulated body fluid and its modified fluids were investigated for three kinds of bioactive glasses, four of bioactive galss-ceramics and two of bioactive sintered ceramics, in comparison with two kinds of non-bioactive glass-ceramics, by means of Fourier transform infrared reflection spectroscopy, thin-film X-ray diffraction and scanning electronmicroscopic observation.
As a result, it was found that all the examined bioactive ceramics including glasses formed a thin layer a apatite similar to the natural bone apatite in its composition and structure on their surfaces in a simulated body fluid, ion concentrations of which were almost equal to those of the human blood plasma. Such apatite layer was, however, not formed on the non-bioactive ceramics. Therefore, it was concluded that essential condition for a ceramic to bond to living bone is to form an apatite layer on its surface in a body environment and that bioactivity of a ceramic is predictable from in vitro experiment in which apatite formation on the surface is examined in the simulated body fluid.
|
