1988 Fiscal Year Final Research Report Summary
Correlation of the distribution of a novel neuropeptide, substance K, in the brain with its physiological roles in the central nervous system.
| Project/Area Number |
61480120
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
KAMIYA Hiro-o FUKUOKA UNIVERSITY, 薬学部, 教授 (90028366)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIKAWA Atsushi FUKUOKA UNIVERSITY, 医学部, 助手 (20148878)
TAGAWA Takasuke FUKUOKA UNIVERSITY, 医学部, 教授 (20078736)
HONDA Kenji FUKUOKA UNIVERSITY, 薬学部, 助手 (60140761)
TAKANO Yukio FUKUOKA UNIVERSITY, 薬学部, 助手 (50113246)
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| Project Period (FY) |
1986 – 1988
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| Keywords | Substance P / Substance K (neurokinin A) / Tachykinins / Receptor subtype / 心循環器調節(血圧調節) |
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| Research Abstract |
We studied the physiological characteristics of substance K (SK; neurokinia A) in comparison with those of substance P (SP), because these two tachykinin peptides are derived from a common tachykinin precursor.
(1) The regional localization of SK- and SP-like immunoreactivities (SK-LI and SP-LI) in the brain and peripheral tissues of rats was investigated, and followed by the effects of neonatal treatment of rats with capsaicin on SK-LI and SP-LI. The distribution of SK-LI was similar to that of SP-LI, and ratio of SK to SP was about 1: 1-4. However, the capsaicin treatment of rat caused different changes in the content in various regions of the CNS between SK-LI and SP-LI. (2) Pathways of the striatonigral neuron and of the afferent neuron to the nucleus tractus solitarii (NTS) were demonstrated by a combination of pharmacological and immunochemical studies. These results suggest that SK and SP may be neurotransmitters in these neurons. (3) Neonatal treatment with capsaicin reduced the content of SP-LI in the NTS. Under these conditions, capsaicin-treated rats maintained reflex responses of the renal sympathetic nerve activity to stimulation of baroreceptor. (4) Dimeric analogues of SK and SP COOH-terminal fragments were synthesized and examined the in vivo and in vitro biological activities. Some of dimers showed a highly POtent analogue for a tachykinin receptor subtype.
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[Publications] 高野行夫 他: "Regional distribution of neurokinin A and substance P in the rat CNS. In"Substance P and Neurokinis"edited by Henry,J.L.,Couture,R.,Cuello,A.C.,Pelletier,G.,Quirion,R.and Regoli,D" Springer-Verlag, 3 (1987)
Description
「研究成果報告書概要(和文)」より
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