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1987 Fiscal Year Final Research Report Summary

Changes in somatic exercise reflex originating from chemosenditive muscle afferents and cardiac responses to increased sympathetic activity during exercise in patients with chronic heart failure.

Research Project

Project/Area Number 61480207
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionOsaka University

Principal Investigator

TAKEDA Hiroshi  Osaka University Hospital, 医学部附属病院, 助教授 (20127252)

Co-Investigator(Kenkyū-buntansha) 尾崎 仁  大阪大学, 医学部附属病院, 医員
MATSUYAMA Taizo  Osaka University Hospital, 医学部附属病院, 医員
SATO Hideyuki  Osaka University Hospital, 医学部附属病院, 医員 (70167435)
INOUE Michitoshi  Osaka University Hospital, 医学部附属病院, 教授 (30028401)
OZAKI Hitoshi  Osaka University Hospital
Project Period (FY) 1986 – 1987
KeywordsExercise / Sympathetic activity / Muscle hypoxia / Heart failure / Chronotropic response / Inotropic response / Plasma norepinephrine / 混合静脈血酸素分圧
Research Abstract

To investigate changes in exercise refrex mediated by chemosensitive muscle afferents and cardiac responses to increased sympathetic activity during exercise in patients with chronic heart failure, we analyzed plasma norepinephrine(NE) response to graded muscle hypoxia assessed by mixed venous oxygen tension (PV02) (study 1),and heart rate (HR) and contractile responses to increased plasma NE (study 2) during leg bicycle exercise in normal subjects and patients with chronic heart failure. Study 1: An inverse correlation was observed between log PV02 and log NE in each subject(r=-0.75 to -0.99, mean -0.93). The slope of log PV02-log NE line showed no significant difference between normal subjicts and patients with heart failure. To enhance a degree of muscle hypoxia, we administrated 40 mg metoprolol in heart failure group and perfomed re-exercise study. Metoprolol increased plasma NE with a decrease in PV02. The quantitative relationship between PV02 and plasma NE was not affected by metoprolol (before: log NE=15.7-3.01og PV02,after: log NE=15.1-2.8 log PV02). Study 2: Close linear correlations of HR and contractility to plasma NE were observed in each subject(HR-log NE: r=0.89 to 0.99, mean 0.96 ; contractility-log NE: r=0.68 to 0.99, mean 0.92). The slope of regression lines decreased significantly along with the severity of heat failure. these results suggest that 1) the degree of muscle hypoxia plays an important role in regulation of sympathetic activity during exercise,2) the somatic exercise refrex arc mediated by chemosensitive muscle afferents remains intact in patients with heart failure and 3) the decreased chronotropic and inotropic responses to sympathetic activity are responsible for the exercise intolerance in patients with heart failure.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 井上通敏: 心臓. 18. 742-753 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 井上通敏: 内科. 58. 1317-1322 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 井上通敏: Coronary. 3. 75-80 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hideyuki Sato: Circulation. 75. 213-220 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hideyuki Sato: Automedica. 9. 35 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀正二: Progress in Medicine. 8. 399-402 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Michitoshi,Inoue: "Sympathetic neural control of heart in patients with heart failure during exercise (in japanese)" HEART. 18. 742-753 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Michitoshi,Inoue: "Cardiovascular response to sympathetic activity during dynamic exercise in patients with heart failure (in japanese)" NAIKA. 58. 1317-1322 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Michitoshi,Inoue: "Dynamic exercise test in patients with chronic heart failure (in japanese)" Coronary. 3. 75-80 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hideyuki,Sato: "Hemodynamic effects of the <beta>-adrenoceptor partial agonist xamoterol in relation to plasma norepinephrine levels during exercise in patients with left ventricular dysfunction" Circulation. 75. 213-220 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hideyuki,Sato: "Preserved somatic exercise reflex originating from chemosensitive muscle afferents in patients with chronic heart failure" Automedica. 9. 35 (1987)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1989-03-30   Modified: 2017-04-05  

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