1987 Fiscal Year Final Research Report Summary
Fundamental and Clinical Study on Dynamic Single Photon Emission CT
| Project/Area Number |
61480235
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Radiation science
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| Research Institution | Mie University |
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Principal Investigator |
YAMAGUCHI Nobuo Mie University, School of Medicine, Professor, 医学部, 教授 (90024679)
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| Co-Investigator(Kenkyū-buntansha) |
中村 和義 三重大学, 医学部附属病院, 助手 (60126985)
MATSUMURA Kaname Mie University, Hospital, Assistant, 医学部附属病院, 助手 (70126994)
TAKEDA Kan Mie University, Hospital, Lecturer, 医学部附属病院, 講師 (70106988)
MAEDA Hisato Mie University, Hospital, Lecturer, 医学部附属病院, 講師 (00024703)
NAKAGAWA Tsuyoshi Mie University, School of Medicine, Associate Professor, 医学部, 助教授 (90024801)
NAKAGAWA Tsuyoshi Mie University, School of Medicine, Associate professor (90024801)
NAKAMUR Kazuyoshi Mie University, Hospital, Assistant
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| Project Period (FY) |
1986 – 1987
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| Keywords | Single Photon Photon Emission CT (SPECT) / Regional cerebral blood flow / Gated blood pool scintigraphy / Hepatobiliary scintigraphy / Renal dynamic scintigraphy / Fourier analysis / Transfer function / ファンクショナルイメージング |
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| Research Abstract |
Dynamic single photon emission CT (SPECT) was performed using a SPECT system with repeatedly rotating opposed gamma cameras. Fundamental and clinical studies were made on the development and clinical application of three dimensional functional imaging. 1. Fundamental study. Methods for data aquisition and absorption were evaluated in relation to resolution, sensitivity and uniformity. The effect of the artifact on the image quality, which is produced by the alteration of radioactivity during data collection, were estimated by a simulation study. The results of 1.5% with the alteration rate of 10%, 2.8% with the rate of 30%, 3.3% with the rate of 50% indicated that the effect of the artifact was not a major problem for image quality. 2. Clinical study. (1) Three dimensional cerebral blood flow functional imaging: SPECT data coliected every 30 sec were analized by the method proposed by Kanno and Lassen to make tomographic images of cerebral blood flow. It was shown that this method was
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usefull in the diagnosis of such mild cerebrovascular diseases as not seen on X-ray CT and in the evaluation of the effect of surgicalf therapy. (2) Gated blood pool study: Gated blood pool SPECT data were aquired using Tc-99m-RBC as a tracer. Reconstructed images were processed by rotation of the images, removal of the data over right ventricle, summation of the tomographic data and fourier analysis to obtain phase and amplitude images which are either parallel or perpendicular to long axis of left ventricle. In the diagnosis of ischemic heart disease, this method was particulary useful in the evaluation of wall motion abnormalities in inferior, and posterior walls. (3) Tc-99m-PMT hepatobiliary functional imaging: One min serial SPECT data were analized by the mathematical deconvolution using time-activity curve (TAC) over the heart as input and TAC over each element of liver images as output function to construct functional images of effective blood flow and transit times. Although there were significant negative correlations between each of total and regional blood flow and mean transit time (MTT) in normals and cases with liver cirrhosis, there were some cases with normal regional blood flow and MTT againstg decreased total blood flow. (4) Tc-99m-DTPA renal functional imaging: Using the same method of deconvolution analysis functional images of GFR and MTT were made. These images were useful in differentating pathophysiology of focal diseases with prolonged MTT and decreased GFR from those with prolonged MTT and normal GFR. Less
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