1988 Fiscal Year Final Research Report Summary
Study on mechanism of development of nasal hyperreactivity in nasal allergy.
| Project/Area Number |
61480354
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Chiba University, School of Medicine (1988)
Akita University (1986-1987) |
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Principal Investigator |
AKIYOSHI Kinno Chiba University, School of Medicine., 医学部, 助教授 (70009497)
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| Project Period (FY) |
1986 – 1988
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| Keywords | Nasal Hyperreactivity / Inflammatory cells / SRS-A / PAF / Nasal Allergy / Autonomic Nerve Receptors / 好塩基球 / 鼻粘膜 |
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| Research Abstract |
Studies were perfomed on kinetics of inflammatory cells, chemical mediators in the nasal mucasa and in the nasal lavage fluid after antigen challenge in subject with Japanese cedar pollinosis and also in guinea pigs sensitized with ovalbumin. Changes of nasal reactivity to histamine and changes of autonamic nerve receptors in the nasal mucosa after antigen challenge and after nasal challenge with various chemical mediators were also avaluated. Present studies indicate that hyperreactuvity of the nasal mucasa characteristic of nasal allergy was induce by direct of chemical mediators, especially of SRS-A and PAF and by the changes of density of outonomic nerve receptors in the nasal mucosa and by various inflammtory cells induced secondarily by chemical mediators. Hyposensitization therapy caused significant decrease of nasal reactivity to histamine which was consistant with significant decrease of inflammatory cells in the nasal lavage fluid after antigen challenge.
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