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1987 Fiscal Year Final Research Report Summary

Mechanisms of stress analgesis: vasopressin hypothesis

Research Project

Project/Area Number 61490029
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field 広領域
Research InstitutionJichi Medical School

Principal Investigator

HAMAMURA Mitsuko  Department of Physiology, Jichi Medical School, 医学部, 講師 (90118456)

Co-Investigator(Kenkyū-buntansha) ONAKA Tatsushi  Department of Physiology, Jichi Medical School, 医学部, 助手 (90177254)
Project Period (FY) 1986 – 1987
KeywordsVasopressin / Stress / Stress analgesis / Posterior Pituitary / Noxious stimuli / Pain / Hypothalamus / 下垂体
Research Abstract

Introduction: Footshocks (Fs) have been shown to induce 'analgesis' as determined by prolongation of latency of tail flick (TF) after noxious heat stimuli. Recently we have demonstrated that a variety of noxious stimuli excite putative vasopressin (VP)- secreting neurones in the supraoptic nucleus. VP unjected systemically was reported to prolong TF latency. It is therefore possible that noxious stimuli may release VP into the plasma and this VP may in turn produce an increase in threshold of TF after FS. Results: Effects of FS on plasma VP; FS (50 Hz, 60 s, 3mA) increased plasma VP in rats (about 30 pg/ml). The increase was related to the FS intensity. Quantification of thermal threshold; We measured tail surface temperature at which TF reflex occurred in the conscious rat using a fine thermocouple. Effects of FS on thermal threshold; Tail surface temperature at TF increased after application of the FS in a intensity-related manner. These data are consistent with the earlier reports t … More hat FS prolonged latency of TF. Effects of I.v.vp; I.V. injected VP at a dose of more than 0.5 ([TA.micrn.])g/kg increased thermal threshold of TF significantly. Plasma VP after an I.V.VP injection at this dose is calculated to be much higher than the level after the FS, assuming that the injected VP would be distributed immediately and evenly in the whole plasma. Effects of posterior pituitary stimulation; Stimulation of the posterior pituitary did not increase effectively thermal threshold of TF, whereas the stimulation increased plasma VP up to about 450 pg/ml. Effects of VP V1-receptor antagonist; VP V1-receptor antagonist injected I.V. decreased the increase after I.V. VP (1.6 <micrn>g/kg) in a dose-related manner (5 - 150 <micrn>g/kg. The antagonist (5 <micrn>g/kg) also blocked the threshold increase after FS. Conclusion: These data lead us to conclude that plasma VP increased after FS dose not mediate a footshock-induced increase in thermal threshold of TF. Since FS have been shown to decrease VP in the brain and the VP V1-receptor antagonist is known to cross the blood-brain barrier, the possibility remains to be tested that FS may release VP within the brain and the VP may in turn mediate the FS-induced increase in threshold temperature of TF. Less

  • Research Products

    (26 results)

All Other

All Publications (26 results)

  • [Publications] M. Hamamura: Journal of the Physiological Society of Japan. 48. 400 (1986)

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      「研究成果報告書概要(和文)」より
  • [Publications] T. Onaka: Journal of the Physiological Society of Japan. 48. 395 (1986)

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      「研究成果報告書概要(和文)」より
  • [Publications] M. Hamamura: Neuroendocrinology, Abstracts of the 1st International Congress of Neuroendocrinology. 42 (1986)

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  • [Publications] T. Onaka: Neuroendocrinology, Abstracts of the 1st International Congress of Neuroendocrinology. 61 (1986)

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  • [Publications] M. Hamamura: Proceedings of the international Union of Physioogical Sciences. 16. 508 (1986)

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  • [Publications] T. Onaka: Proceedings of the international Union of Physioogical Sciences. 16. 509 (1986)

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  • [Publications] M. Hamamura: Japanese Journal of Physiology. 36. 921-933 (1986)

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  • [Publications] T. Onaka: Japanese Journal of Physiology. 36. 1253-1260 (1986)

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  • [Publications] T. Onaka: Japanese Journal of Physiology. 36. 1261-1266 (1986)

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  • [Publications] K. Shibuki: Brain Research. 410. 140-142 (1987)

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  • [Publications] M. Hamamura: Neuroscience Research. Suppl. 3. S112 (1986)

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  • [Publications] T. Onaka: Neuroscience Research. Suppl. 3. S114 (1986)

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  • [Publications] Hamamura, M.: Proc. Brain Opioid Reproduction.20 (1987)

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  • [Publications] Onaka, T.: Exp. Brain Res.(1988)

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  • [Publications] Onaka, T.: Neurosci. Res.(1988)

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  • [Publications] Hamamura, M.: Neurosci. Res. Suppl.(1988)

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  • [Publications] Hamamura, M.: Jpn. J. Physiol.(1988)

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  • [Publications] 浜村みつ子: "文部省特定研究神経難病の発症機構昭和61年度研究業績集「バゾプレシン鎮痛仮説の検証:尾逃避反射装置の試作」" 文部省特定研究神経難病の発症機構・総括班, (1987)

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  • [Publications] T. Onaka: "Potentiation of vasopressin secretion by footshocks in rats." 36. 1253-1260 (1986)

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  • [Publications] T. Onaka: "Suppression of vasopressin secretion by classically conditioned stimuli in rats." 36. 1261-1266 (1986)

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  • [Publications] K. Shibuki: "Synergistic interactions between footshocks and nonosmotic hypovolemia on vasopressin secreton in rats." 410. 140-142 (1987)

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  • [Publications] Hamamura, M.: "Increase in tail-flick threshold after footshock: blocking by vasopressin-receptor antagonist but no by naloxone." Proc. Brain Opioid Reproduction.20 (1987)

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  • [Publications] Hamamura, M.: "Vasopressin-receptor antagonist blocks a footshock- induced increase in temperature at tail flick in rats." Neurosci. Res. Suppl.in press. (1988)

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  • [Publications] Onaka, T.: "Vasopressin secretion: suppression after light and tone stimuli previously paired with footshocks in rats." Exp. Brain Res.in press. (1988)

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  • [Publications] Onaka, T.: "Bimodal effects of noxious stimuli on vasopressin secretion in rats." Neurosci. Res.in press. (1988)

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  • [Publications] Hamamura, M.: "Plasma vasopressin is not involved in footshock-induced analgesis in rats." Jpn. J. Physiol.submitted. (1988)

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Published: 1989-03-30  

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