1987 Fiscal Year Final Research Report Summary
Synthesis of Sequential Polypeptides Having Biological Activity
| Project/Area Number |
61550668
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
高分子合成
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| Research Institution | Hokkaido University |
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Principal Investigator |
NISHI Norio Hokkaido University, Instructor Fac. of Sci., 理学部, 助手 (70001857)
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUMI Akihiro Hokkaido University, Professor Fac. of Eng., 工学部, 教授 (80000884)
TOKURA Seiichi Hokkaido University, Professor Fac. of Sci., 理学部, 教授 (40000806)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Diphenylphosphoryl Azide(DPPA) / Polymerization / Sequential Polypeptides / Conformation / Biopolymers / DNA / 精子特異性塩基性タンパク質 / DNA凝集能 |
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| Research Abstract |
Recently, we found the new synthetic method of polypeptides to employ diphenylphosphoryl azide(DPPA) as a polymerization reagent. This method is adequate for the polymerization of peptides to give protein-like sequentialpolypeptides. In the present investigation, various types of biologically active sequential polypeptides were prepared, and their conformation and the interactions with biopolymers such as DNA were investigated to clarify their possibility as biofunctional materials. The medical application of these sequential polypeptides were also examined.
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