1988 Fiscal Year Final Research Report Summary
Cholesterol-degrading, -binding and -synthesis inhibiting materials from dairy microorganisms.
| Project/Area Number |
61560325
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
畜産化学
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| Research Institution | Nagoya University |
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Principal Investigator |
WATANABE Kenji Nagoya University, Faculty of Agriculture, 農学部, 助教授 (70023447)
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| Project Period (FY) |
1986 – 1988
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| Keywords | Cholesterol / Cholesterol oxidase / 酸性多糖 |
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| Research Abstract |
Dietary cholesterol has been considered a contributing factor in the pathogenesis of atherosclerosis and hypercholesterolmia in humans. This study was initiated to control the problems due to dietary cholesterol with the action of food microorganism.
1. Degradation of egg yolk cholesterol: Egg is a high cholesterol diet. the degradation of egg yolk cholesterol was investigated with Rhodococcus equi No. 23, a strain previously isolated from butter. Egg yolk cholesterol was degraded via 4-cholesten-3-one into nonsteroid compounds with almost no accumulation of steroid intermediates. 2. Cholesterol-dinding materials: some microorganisms (R. bronchialis, bacillus sp., Arthrobacter sp., Dandida kefyr and C. tenuis) that produce the cholesterol-binding materials were isolated. All of their materials belonged to the acidic polysaccharide containing uronic acid.
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