• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1987 Fiscal Year Final Research Report Summary

An experimental study of the parathyroid gland under hypergravity environment: Effects of Agents

Research Project

Project/Area Number 61570008
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionGIFU UNIVERSITY

Principal Investigator

ISONO Hidio  GIFU UNIVERSITY, SCHOOl OF MEDICINE, 医学部, 教授 (50021358)

Project Period (FY) 1986 – 1987
KeywordsHypergravity / Hamster / Parathyroid Gland / Electron Microscopy / Autonomic Nerve Agent / 自律神経薬
Research Abstract

Fine structure of the parathyroid glands of golden hamsters injected inorganic salts (CaCl_2, Mg@5o_4, Na_2HPO_4) and adrenergic agents (isoproterenol, propranolol, adrenalin, noradrenalin) under 5 gravity environment was studied (Ca, Mg, P, IP, Pro, A, Na, Ca・ 5G, Mg・ 5G, P・ 5G, IP・ 5G, Pro・ 5G, A・ 5G, and NA・ 5G groups). Immunocytochemical localization of parathyroid hormone (PTH) in the chief cells was examined. Vascular casts of the parathyroid glands were studied in the golden hamsters of control, 5G, A, A・ 5G, NA and NA ・ 5G groups by scaning electron microscopy.
Protein A-gold particles were observed on secretory granules, large secretory granules and Golgi vacuoles showing PTH positive nature. The Golgi complexes and cisternae of the granular endoplasmic reticulum were significantly increased in the P, P・ 5G, Mg・ 5G, IP, IP・ 5G, A, A・ 5G, NA and NA・5G groups and decreased in the Ca, Ca・ 5G and Pro groups as compared with those of control animals. There were no significant differences between the control and A- or NA-treated animals with regard to the vascular architecture. Accordingly, hyperactivity of the parathyroid gland in A, A ・ 5G, NA and NA・ 5G groups may reflect direct effects of A and NA to the parathyroid chief cells. Under hypergravity environment, supresseion of the parathyroid function with Pro may be relieved and stimulation with IP, A and NA may be increased.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] 正村静子: 病態生理. 5. 307-310 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 磯野日出夫: 病態生理. 5. 385-388 (1986)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩崎雄二: 臨床電顕誌.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] SHIZUKO SHOUMURA: Histol.Histopathol.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] SHIZUKO SHOUMURA: Acta anat.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] SHIZUKO SHOUMURA: Acta anat.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] SHIZUKO SHOUMURA: "Parathyroid Gland I. Normal Structure" MEDICINA PHILOSOPHICA. 5. 307-310 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] HIDEO ISONO: "Parathyroid Gland II. Fine Structure under Hyper-and Hypofunction" MEDICINA PHILOSOPHICA. 5. 385-388 (1986)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] YUJI IWASAKI: "Effects of Propranolol on the Fine Structure of the Hamster Parathyroid Gland" J.Clin. Electronmicroscopy.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] SHIZUKO SHOUMURA: "Effects of Isoproterenol on the Fine Structure of the Hamster ParathyroidGland" Histol. Histopathol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] SHIZUKO SHOUMURA: "Effects of Hypergravity Environment on the Ultrastructure of the Golden Hamster Parathyroid Gland" Acta anat.

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1989-03-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi