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1987 Fiscal Year Final Research Report Summary

Studies on Asphyxia: Electron microscopic, immunohistochemical and biochemical studies.

Research Project

Project/Area Number 61570294
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Legal medicine
Research InstitutionSapporo Medical University

Principal Investigator

MORITA Masahiko  Dept. of Legal Medicine, 医学部, 教授 (00045353)

Co-Investigator(Kenkyū-buntansha) AKINO Toyoaki  Dept. of Biochemistry ( section 1 ), 医学部, 教授 (80045377)
TABATA Noriko  Dept. of Legal Medicine, 医学部, 助手 (30128524)
森田 匡彦  札幌医科大学, 医学部, 教授 (00045353)
Project Period (FY) 1986 – 1987
KeywordsAsphyxia / Hypoxia / Lung surfactant / Immunohistochemistry / モノクローナル抗体
Research Abstract

Studies on asphyxia were performed by using rats inhaled air with decreased oxygen. The air was prepared by using fluorometer, mixing carbon dioxide, methane and carbon monoxide gases. The electron microscopic study showed the debris-like structures in which the lattice like structure and/or tubular myeline which is well-known as the morphological expression of lung surfactant. Biological analysis revealed that the protein and phospholipids increased as 5 and 2 and/or 3 times as much compared with those of normal rat's lung lavage. Immunohistochemical research was also performed using the monoclonal anti-body to the human lung surfactant apo-protein. The active secretion of the surfactant in such hypoxic state mentioned above and in the human lung in a case of strangulation as well by this study. In conclusion, the increase in the secretion of the lung surfactant in hypoxic state, should be attributed to the decrease of the oxygen in the inhaled air and/or decreased tension of oxygen in the alveoli.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Masahiko Morita: Forensic Sci.Int.27. 81-92 (1985)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masahiko Morita: In press in the Forensic Sci.Int.(1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masahiko Morita: In press in the Forensic Sci.Int.(1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroki Takahashi: In preparation.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masataka Fujiwara: Sapporo Med.J.57. (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masahiko Morita: "Studies on Asphyxia: On the changes of the alveolar walls of rats in the hypoxic state." Forensic Sci. Int.27. 81-92 (1985)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masahiko Morita: "Studies on Asphyxia: On the changes of the alveolar walls of rats in the hypoxic state. II. The hypoxic state produced by carbon dioxide and methane gases." Forensic Sci. Int.In press. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masahiko Morita: "Studies on Asphyxia: On the changes of the alveolar walls of rats in the hypoxic state. III.The hypoxic state by carbon Monoxide gas." Forensic Sci. Int.In press. (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroki Takahashi: "Studies on Asphyxia: On the changes of the alveolar walls of rats in the hypoxic state. IV. Accumulation of pulmonary surfactant phospholipids in the alveoli of rats in the hypoxic state."

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masataka Fujiwara: "An immunocytochemical study on human pulmonary surfactant and its application to legal medicine." Sapporo Med. J.57. (1988)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1989-03-30  

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