1987 Fiscal Year Final Research Report Summary

Effects of hormones on enzynoes in rat nephron segment.-For the protection of isclemmic acute renal failure-

Research Project

Project/Area Number	61570306
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	内科学一般
Research Institution	Tokyo Medical and Dental University
Principal Investigator	TOMITA Kimio Tokyo Medical and Dental University, 医学部, 講師 (40114772)
Project Period (FY)	1986 – 1987
Keywords	Na-K-ATPase / Vasopressin / Tubular enzzme / Kininase / Anyiotensin-I converting enzyme / Aldosterone / 急性腎不全
Research Abstract	Effects of vasopressin, aldosteronl on enzymes were investigated in rat nepbron segments. Vasopressin stimulated Na-K-ATPase activity in rat cortical collecting duct. The stimulative effects were detected following the treat ment about 3 days. Simian stimulation occured 7th day treat ment's. Kininase may be one of the rate limiting factor in the kallikrein-kimin system. Kininase was also invert・gcted along the nepluon. Kinimase was detected in medullary Collecting duct. The acticity acereased following the trecut ment of aldosterone. for 3.7 days. These hormcrce may have protective effect eithen by stimulating Na-K-ATPase or by decreasing kininase.