1987 Fiscal Year Final Research Report Summary
Subrenal capsule assay of liver tumor obtained by percutaneous aspiration biopsy
| Project/Area Number |
61570358
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Gastroenterology
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| Research Institution | Kurume University |
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Principal Investigator |
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| Project Period (FY) |
1986 – 1987
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| Keywords | Subrenal capsule assay (SRCA) ; Liver tumor ; Aspiration biopsy / Drug sensitivity test / subrenal capsule assay(SRCA) / 吸引生検 / 肝癌 / 免疫抑制剤 |
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| Research Abstract |
In order to increase the effect of chemotherapy against liver cancer, subrenal capsule assay (SRCA) was underwent employing the specimen obtained by fine needle biopsy.
The 18 specimens (1l hepatocelular carcinoma, 4 metastatic liver cancer and 3 cholangiocellular carcinoma of the liver) were obtained by fine needle biopsy under the guidance of ultrasonographic eqquipment. Then the 1 mm cubic specimen was transplanted to subrenal space of BDF1 mice which were premedicated by cyclophosphamide 150mg/kg or cyclosporin A 60mg/kg, and SRCA using anticancer drug (CDDP,ADR and MMC) was performed in 11 cases of 18 experiments.
In the SRCA, the overa11 ruccessful growing rate of implanted tumors was 88.9% (16/18) and the success rate of each tumor type was as follows : hepatocellular carcinoma 81.8%, metastatic liver cancer 100% and cholangiocellular carcinoma 100%.
In conclusion, the advantage of SRCA using the fine needle biopsy specime is : 1) it has a high seccessful rate, 2) it allows rapid evaluation and 3) it can be applied for hepatic cancer therapy.
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Research Products
(1 results)
