1987 Fiscal Year Final Research Report Summary
Experimental study on high-dose chemotherapy with autologous bone marrow transplantation against solid tumor
| Project/Area Number |
61570370
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Toyama Medical and Pharmaceutical University |
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Principal Investigator |
MIZUSHIMA Yutaka lst Department of Internal Medicine, Toyama Medical and Pharmaceutical Universit, 附属病院, 助手 (20174021)
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| Project Period (FY) |
1986 – 1987
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| Keywords | High-dose chemotherapy / 大量化学療法 / 自家骨髄移植 |
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| Research Abstract |
In order to know which anticancer drugs are more appropriate for high-dose chemotherapy (HC) with autologous bone marrow transplantation (BMT) in cancer therapy, we tested six drugs (ACNU, ADR, CY, MMC, VDS, VP-16) in sprague-Dawley (SD) rats. Two or three varying doses of each drug were given iv on day O, followed by syngeneic BM cells (5x10^7,iv) on day 2, and animals were observed for over 60 days. ADR caused a high rate of peripheral neuropathy rather than myelosuppression death, so ADR was considered to be inappropriate for HC-BMT. Among other five drugs, a beneficial effect of BMT was observed only with CY (300-400 mg/kg) and ACNU (40 mg/kg). In order to increase the beneficial effect of BMT, administration ways of CY and ACNU were designed, and better survival curves were obtained in the following administration groups; 1) (CY 200 mg/kg, days 0 & 1) BMT> (CY 400 mg/kg, day 0) BMT, (ACNU 20 mg/kg, day 0 & 1) BMT> (ACNU 40 mg/kg, day 0) BMT, 2) (CY 200 mg/kg ACNU 20 mg/kg, day 0) BMT>(CY 400 mg/kg or ACNU 40 mg/kg, day 0) BMT, 3) (CY 200 mg/kg, day 0) (acanau 20 mg/kg, day 1) BMT> (ACNU 20 mg/kg, day 0 ) (CY 200 mg/kg, day 1) BMT.
Among six anticancer drugs tested in this study, CY and ACNU were suggested to be more appropriate drugs for HC-BMT, but devices for reducing drug toxicity are considered to be necessary for increasing the beneficial effect of BMT.
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