1987 Fiscal Year Final Research Report Summary
Centrally mediated cardiovacular depressant actions of arginine vasopressin in Brattleboro rat and spontaneously hypertensive rat.
| Project/Area Number |
61570401
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | TOHOKU UNIVERSITY |
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Principal Investigator |
IMAI Yutaka Second Department of Medicine, Tohoku University, 第二内科, 助手 (40133946)
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| Co-Investigator(Kenkyū-buntansha) |
ABE. Keishi Department of clinical biology and hormonal regulation, 病態液性調節学講座, 教授 (60004777)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Vasopiressin / Long-Evans rat / Brattleboro rat / Spontaneous hypertensive rat / Cerebrolateral ventricle / Depressor effect / 徐脈作用 |
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| Research Abstract |
The cardiovascular effects of centrally administered arginine vasopressin were studied in stroke-prone spontaneously hypertensive rats and Wistar-Kyoto rats. Arginine vasopressin was infused intracerebroventricularly into conscious rats at a rate of 2 pg/kg/min (4.6 <micrn>/hr) for 21 hours, and blood pressure and heart rate were monitored. Agrinine vasopressin caused transient hypertension and tachycardia in Wistar-Kyoto rats, whereas it induced delayed hypotension and bradycardia in stroke-prone spontaneously hypertensive rats. The effects on the latter lasted for 24 to 72 hours after cessation of the infusion. Intravenous administration of arginine vasopressin at a rate of 2 pg/kg/min did not cause any change in blood pressure and heart rate in these rats. These results suggest that arginine vasopressin acts centrally to depress cardiovacular activites, at least in stroke-prone spontaneously hypertensive rats.
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