1988 Fiscal Year Final Research Report Summary
Experimental studies on myocardial mechanics following coronary reperfusion
| Project/Area Number |
61570434
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
鎌田 勲昭 医学部〓1内科学, 助手
KOKA Hironari Kinki University School of Medicine, 手 (50215208)
SHIMIZU Minoru Kinki University School of Medicine, 講師 (20178990)
小川 巌 医学部〓1内科学, 講師
ODA Akio Kinki University School of Medicine (20169303)
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| Project Period (FY) |
1986 – 1988
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| Keywords | Acute myocardial infarction / Coronary thrombolysis / Coronary stenosis / 心筋サルベージ |
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| Research Abstract |
The left anterior descending coronary artery in dogs was occluded of study the myocardial mechanics following reperfusion regarding 3 questions:
1) Time course change of wall thickness at the occluded area 2) Effects of mannitol to salvage the infarcted myocardium 3) Effects of residual coronary stenosis on the myocardial salvage. We found that after reperfusion, there is a biphasic increare in wall thickness, possibly related to reactive hyperemia and myocardial edema. Myocardial salvage was evident by Mannitol infusion at the outer wall of the infarcted area, possibly reflecting the free radical scavenging action of Mannitol. Residual stenosis of more than 99% coronary stenosis causes deleterious effects on myocardial salvage and thus we concluded the necessity of emergent PTCA. We could reach conclusions each on 3 items during this budget period.
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