1987 Fiscal Year Final Research Report Summary
Differentiation of Alzheimer Type Demential and Cerebrovacular Dementia in terma of Ultransonic Quantitative Measurement of Common Carotid Blood Floe Volume and EEG Power Specturm Analysis.
| Project/Area Number |
61570533
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Psychiatric science
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| Research Institution | The Jikei University School of Medicine |
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Principal Investigator |
SHIMIZU Makoto The Jikei University School of Medicine, 医学部, 助教授 (90056622)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Hiroshi The Jikei University School of Medinice, 医学部, 講師 (20151532)
NISHIKAWA Yoshinobu The Jikei University School of Medicine, 医学部, 講師 (00130188)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Carotid blood flow / Cerebrovasular dementia / Alzheimer type dementia / Hardning index of carotid artery / Dysphoric mood / EEG / 頸動脈血流量 / 脳波周波数(パワー比)分析 |
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| Research Abstract |
1. According to common carotid blood flow volume,the groups of subjects are hierarchized as; normal control group(NC)>cerebrovacular dementia,iocalized type(CVD-L)>cerebrovasular dementia,diffuse type(CVD-D)<similar equal>Alzheimer type dementia(DAT). 2.According to hardening index of carotid of carotid after(Ve),the groups of subjects are hierachized as: CVD-D>CVD-L>DAT<similar equal>NC. Accordingly,(Ve) can be utilized to differenciate CVD (CVD-D in particualr) from DAT. 3.In demented subjests,more lateralities of carotid blood flow volume were found the among non-demented subjects.Most prominently among DAT(76,9%). 4. Presence of dysphoric mood change was much more common among those with left side lateralization(81.8%) than those with right side lateralization(16.0%). 5.EEG power spectrum analysis was used in comparison among CVD-D and DAT in dementia-sevirity matched groups.Our results are as follows;(1)In earlier stage of dementia, and increase of <theta> hand power ratio and a dectrasc of fast<alpha> band power ratio were noted. (2) In an advanced stage of dementia,EEG change is of different quality,that is,an increase of <delta> band power ratio and a decrease of slow-<alpha> band power rati. DAT group tend to exhibit this change earlier than CVD-D group.(3)At very severely demented terminal satage however, CVD-D group exhibit similar change and distinction between the two dies away.
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