1988 Fiscal Year Final Research Report Summary

A study on serum lipid levels and blood rheology in chronic occlusive arterial disease

Research Project

Project/Area Number	61570604
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	Tokyo Medical and Dental University
Principal Investigator	MISHIMA Yoshio Tokyo Medical Dental University : Professor, 医学部, 教授 (00010158)
Co-Investigator(Kenkyū-buntansha)	岡早百合東京医科歯科大学, 医学部, 医員 TOMINAGA Syuji Tokyo Medical Dental University : Assistant, 医学部, 助手 (10207615) OKA Sayuri Tokyo Medical Dental University : Resident
Project Period (FY)	1986 – 1988
Keywords	arterioscrelotic obliteration (ASO) / atherosclerosis / endothelial injury / 内膜肥厚
Research Abstract	(1) For analysis and examination of serum lipid, we selected 40 patients from those with ASO who had been treated in our hospital. As for tatal cholesterol in our study, there was no noticeable difference between the patient and control groups. ASO group exhibited high triglyceride levels and increased pre- lipo-protein, namely, increased VLDL cholesterol. This study results suggest that hyper lipidemia associated with elevated VLDL cholesterol could play a more important role in pathogenesis of ASO. (2) A study on serum lipid and atherosclerosis in experimental animal. It shows that high-cholesterol diet proceed the intimal prolifilation and atherosclerotic change at the anastomotic lesion. It suggests that serum cholesterol level is an important factor of the atheroscrelosis. (3) A study on endothelial injury and antiplatelet drug. After endotherial injury, intimal prolifilation was shown. Smooth muscle cell prolifetation is one of the major factor, but there was no difference between control group and drug diet group.