1987 Fiscal Year Final Research Report Summary
A Treatment for Ischemic Ulcers by a Foot Bath Therapy Using High Oxygen Soluble Fluid
| Project/Area Number |
61570605
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IWAI Takehisa Tokyo Medical & Dental Univ. School of Med. Lecturer, 医学部, 講師 (90111591)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Ischemic ulcer / foot bath therapy / 虚血性潰瘍 |
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| Research Abstract |
I devised a new treatment for ischemic ulcer in which the diseased foot is soaked in perfluorodecalin, a fluorocarbon. Pure oxygen bubbles emerge from the perfluorodecalin, and dissolved oxygen levels reach 35% by volume within 60 minutes. Three hours storage of the saphenous vein in the oxygenated fluid demonstrated very minimum ultrastructual changes of the intimal cells. And permeation speed and oxygen content througgh the damaged mouse skin to the phosphate buffer solution were studied. This study suggested that oxygen could pass through the damaged skin quickly.
For clinical use, soaking bath tub was made with thermostat, fluid filter, fluid churing and anti-bacterial lamp. The solution is placed in a bath once or twice a day for 2-3 hours and pure oxgen is allowed to bubble through it (3-51/min.). Nine patients were treated by this technique. No drugs which seemed to be effective for ischemic ulcers were used during the treatment. Ischemic ulcers in three patients (5x5, 23x6 and 10x5mm) healed completely within two weeks and had no recurrences. In six patients, the ulcers showed 30-70% reduction in size within 4-14 days. Four of them later underwent arterial reconstruction which resulted in complete healing of the ulcers. In two patients, the ulcers reverted to former size 6 to 12 months after cessatoin of perfluorodecalin bath therapy.
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