1987 Fiscal Year Final Research Report Summary

Detection of oncogeme and hepatitis virus in small hepatocellular carcinoma by In Situ Hybridization method

Research Project

Project/Area Number	61570606
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	Hamamatsu university school of medicine
Principal Investigator	ITO Yoshimi Chiba University, School of Medicine, 医学部, 教授 (30107809)
Co-Investigator(Kenkyū-buntansha)	石原康守浜松医大, 医学部, 助手 (00193350) 小谷野憲一浜松医大, 医学部, 助手 (60126810) IMAZEKI Fumio Chiba university, School of Medicine OKUDA Kunio Chiba University, School of Medicine
Project Period (FY)	1986 – 1988
Keywords	in situ hybridization method / oncogene / small hepatocellular carcinoma / 炎症 2.レーザー血管吻合
Research Abstract	Ras and myc oncogenes were studied in small hepatocelullar carcinoma (HCC)by in situ hybridization technique. The expression of ras oncogene was increased in 2 of 3 HCC (less than 3 cm), but not in 2 small hyperplastic nodules. Increased expression of ras and myc genes were not found in 7 autopsy HCC specimens, nor in cirrhotic livers. It is indicated that in situ hybridization technique could not only elucidate the mechanism of hepatocarcinogenesis but also become powerful diagnostic tool.

(3 results)