1987 Fiscal Year Final Research Report Summary

Detection of oncogeme and hepatitis virus in small hepatocellular carcinoma by In Situ Hybridization method

Research Project

Project/Area Number	61570606
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	General surgery
Research Institution	Hamamatsu university school of medicine
Principal Investigator	ITO Yoshimi Chiba University, School of Medicine, 医学部, 教授 (30107809)
Co-Investigator(Kenkyū-buntansha)	石原康守浜松医大, 医学部, 助手 (00193350) 小谷野憲一浜松医大, 医学部, 助手 (60126810) IMAZEKI Fumio Chiba university, School of Medicine OKUDA Kunio Chiba University, School of Medicine
Project Period (FY)	1986 – 1988
Keywords	in situ hybridization method / oncogene / small hepatocellular carcinoma / 炎症 2.レーザー血管吻合
Research Abstract	Ras and myc oncogenes were studied in small hepatocelullar carcinoma (HCC)by in situ hybridization technique. The expression of ras oncogene was increased in 2 of 3 HCC (less than 3 cm), but not in 2 small hyperplastic nodules. Increased expression of ras and myc genes were not found in 7 autopsy HCC specimens, nor in cirrhotic livers. It is indicated that in situ hybridization technique could not only elucidate the mechanism of hepatocarcinogenesis but also become powerful diagnostic tool.