1988 Fiscal Year Final Research Report Summary
Study of alloantigen specific human suppressor T cell clone and its clinical application
| Project/Area Number |
61570612
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | HIROSHIMA UNIVERSITY |
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Principal Investigator |
FUKUDA Yasuhiko Hiroshima Univ. School of Medicine. Associate Prof., 医学部, 講師 (40093801)
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| Co-Investigator(Kenkyū-buntansha) |
ASAHARA Tosimasa Hiroshima Univ. School of Medicine. Assistant, 医学部, 助手 (70175850)
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| Project Period (FY) |
1986 – 1988
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| Keywords | Mixed lymphocyte culture / Human suppressor T cell clone / 非特異的免疫抑制因子 |
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| Research Abstract |
We established 72 T cell clones generated from human one way MLC by recombinant IL-2 and feeder cells. Only one clone, -1-C5, had suppressor T cell like fuction, that is this clone showed ability to suppress the MLK but lacked cytotoxic property.
-1-C5 clone was not restricted by MHC(HLA-A,B,DR,DG). Its surface marker was CD3 and CD8 psitive.
The mechanism od suppression by this clone was due to soluble factor. The soluble factor was produced from this clone under the influence of gamma irradiated original MLR. Interestigly this factor showed non specific suppression. Like this soluble factor may be useful in the field of organ transplantation clinically in the future.
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