1987 Fiscal Year Final Research Report Summary
Gastric Mucosal Damage and Prostaglandin E_2 in Rats with Renal Failure
| Project/Area Number |
61570656
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Wakayama Medical College |
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Principal Investigator |
UESAKA Kzauo Wakayama Medical College, 医学部, 助手 (80184919)
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| Co-Investigator(Kenkyū-buntansha) |
児玉 悦男 和歌山県立医科大学, 医学部, 助手
KODAMA Etsuo Wakayama Medical College
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| Project Period (FY) |
1986 – 1987
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| Keywords | Renal failure / Gastric mucosal damage / Prostaglandin E_2 / Stress ulcer / Solcoseryl / 迷走神経切離術 |
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| Research Abstract |
In order to study the role of gastric mucosal prostaglandin E_2 (PGE_2) and the effect of PGE_2; of Solcoserly; and of vagotomy on gastric mucosal damage in renal failure, rats with renal failure were prepared by stepwise 4/6 -5/6 nephrectomy.
PGE_2 values tended to decrease in relation to the severity of renal failure. After inducing stress, vagotomy was most effective in suppressing ulcers, followed by Solcoseryl and PGE_2 values in the gastric mucosa decreased when PGE_2 was administered for 7 days, and this finding may have been the result of a negative feedback mechanism. Solcoserly, which is known to increase gatric mucosal PG values, did not have this effect in renal failure. However, the gastric mucus increased most with Solcoseryl. No decreaseein PGE_2 values after vagotomy was observed. Furthermore, as vagotomy induced a decrease in gastric acidity (which is an aggressive factor), it was most effective in suppressing ulceration after stress.
It was concluded as follows in rats with renal failure: 1. PGE_2 values in the gastric mucosa were considered an imporetant factor in gastric mucosal damage. 2. Vagotomy was considered the most effective pretreatment.
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