1987 Fiscal Year Final Research Report Summary
Toxicological assessments of spinally afministered agents ; Especially their effects on Spinal Cord Blood Flow
| Project/Area Number |
61570733
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
麻酔学
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| Research Institution | University of Tsukuba |
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Principal Investigator |
DOHI Shuji Institute od Clinical Medicine, University of Tsukuba, 臨床医学系, 助教授 (40155627)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUMIYA Naoki Institute of Clicical Medicine, University of Tsukuba, 臨床医学系, 講師 (00181751)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Spinal cord blood flow / Cerebral blood flow / Tetracaine / Epinephrine / Butorphanol / Prostagrandine / プロスタグランジン / autoregulation / 呼吸性アルカローシス |
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| Research Abstract |
In order to assess the effects of spinally administered agents on spinal cord blood flow (SCBF), lumbal SCBF and cerebral blood flow(CBF) were measured simultaneously by the hydrogen clearance methods in dogs. The subarachinoid tetracaine, 5mg of lml, produced any significant changes in both SCBF and CBF,although arterial blood pressure decreased significantly after the administration. after subarachinoid eqinephrine, 1008300 and 500 ug/ml, SCBF varied widely but did not change significantly with any of the injections, nor did CBF.
Neihter butorphanol nor PGI_2 analog(OP-41483) affected SCBF when they administered subarachinoidally, though intravenous administration of the latter caused significant changes in SCBF and CBF as well as cerebrospinal fluid pressure. The subarachnoid clonidine produced significant decrease in SCBF.
Although our knowledge regarding SCBF effects of spinally administered agents is still insufficient, several investigators,Crosby in U.S.A., Kozody in Canada, Gordh in Sweeden, also reported the results of their similar studies which agree or disagree our present results.
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