1988 Fiscal Year Final Research Report Summary
Phosphatidylinositol turnover of cancer cell menbrane and development of new treatment of renal cell carcinoma
| Project/Area Number |
61570771
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | Yokohama City University |
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Principal Investigator |
KUBOTA Yoshinobu Associate Professor, 医学部, 助教授 (10106312)
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| Co-Investigator(Kenkyū-buntansha) |
HOSAKA Masahiko Professor, 医学部, 教授 (30106330)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Cell menbrane / Phosphatidylinositol metabolism / Signal transduction / renal cell carcinoma / liposome / リポゾーム / 癌治療 |
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| Research Abstract |
Characteristics of cancer cell menbrane, espicially phosphatidyl-inositol (PI) metabolism of renal cancer cells, were investigated. AND a new approach for treatment of renal cancer depending on these charactristics were preliminary studied.
We found, phosphrylation and PI metabolism were greatly enhanced in cancer cells and, exceptional incorperation of ^<32>P into CDP-diacylglycerol (CDP-DG) was found in some of renal cancer cells.
Furthermore, only these CDP-DG accumulated cells showed an increased c-myc gene expression among the cells tested. The results support the idea that PI cycle might be associated with the activation of c-myc gene expression.
Cytotoxic effects of liposomes of PI from different species like soybean , on human renal cancer cells were studied. Soybean PI liposome specifically killed the renal cancer cells whose PI metabolism were enhanced. And we concluded that PI liposome from different species could be one of the useful new modality for the treatment of renal cancer.
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