1987 Fiscal Year Final Research Report Summary
Immunological studies on the mechanism and treatment of inflammatory ocular diseases
| Project/Area Number |
61570837
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Ophthalmology
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| Research Institution | Hokkaido University |
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Principal Investigator |
OHNO Shigeaki Hokkaido University School of Medicine, 医学部, 助教授 (50002382)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Makoto Hokkaido University Hospital, 医学部附属病院, 助手 (80142727)
ONOE Kazunori Immunological Science, Hokkaido University, 免疫科学研究所, 教授 (40002117)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Inflammatory ocular diseases / HLA / Oligo-2',5'-adenylate synthetase / Interferon / Ciclosporin / Lymphocyte subsets / アデノウイルス |
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| Research Abstract |
The exact cause of inflammatory ocular diseases is obscure, and they run a chronic and protracted course with poor visual prognosis. In this study, immunological mechanisms and immunotherapy of inflammatory ocular diseases were investigated. It was shown that disease susceptibility genes and disease resistance genes were closely associated with the immunogetic mechanisms of the ocular diseases. Activeties of serum gamma interferons and oligo- 2',5'-adenylate synthetase of the lymphocytes were significantly increased in endogenous uveitis. Helper
Experimental studies using animal models are currently progress, and further studies are needed to understand better the true nature of inflammatory ocular diseases.
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Research Products
(14 results)
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[Publications] Ohno,S.: "Acta Rome'86,Proceeclings of the XXV International longress of Ophthalmology,Ron" Cristini,G.,Scudiri,G.,Musini,A.and Maione,M.(Kugler Publications and Ghedini Editore), (1988)
Description
「研究成果報告書概要(和文)」より
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