1987 Fiscal Year Final Research Report Summary

A Novel Antileukemic Sesquiterpene: Synthesis of Racemic Eriolamin.

Research Project

Project/Area Number	61570986
Research Category	Grant-in-Aid for General Scientific Research (C)
Allocation Type	Single-year Grants
Research Field	Chemical pharmacy
Research Institution	Faculty of Phamaceutical Sciences, Hokkaido University
Principal Investigator	YOSHIDA Kiyoshi Faculty of Pharmaceutical Sciences, Hokkaido University, 薬学部, 助手 (60109478)
Co-Investigator(Kenkyū-buntansha)	MORI Miwako Faculty of Pharmaceutical Sciences, Hokkaido University, 薬学部, 助教授 (80001981) WAKAMATSU Takeshi Tsumura Laboratory, 津村研究所, 部長代理 (40001044)
Project Period (FY)	1986 – 1987
Keywords	Antilukemic Sesquiterpene / Eriolanin / Eriolagin / ケテン付加反応
Research Abstract	Eriolanin(1) and eriolanin(2) are novel antileukemic 1,10-seco-eudesmanokides which were isolated from Eriophyllum lanatum Forbes (Compositae) by Kupchan and corworkers during a search for tumor-inhibitory natural products from plant sources. Both eriolanin and eriolangin were found to be possess significant in vivo activity against P388 leukemia in mice and in vitro activity against cell cultures derived from human carcinoma of the nasophargyx (KB). The total synthesis of these natural products has been achived by our investigators in this research project for a term of two years.

(6 results)