1987 Fiscal Year Final Research Report Summary
Synthesis of Sphingosines and Cerebrosides
| Project/Area Number |
61570993
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
NAKAGAWA Masako Faculty of Pharmaceutical Sciences, Chiba University, 薬学部, 助教授 (40009171)
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| Co-Investigator(Kenkyū-buntansha) |
HINO Tohru Faculty of Pharmaceutical Sciences, Chiba University, 薬学部, 教授 (10009160)
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| Project Period (FY) |
1986 – 1987
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| Keywords | スフインゴシン / セラミド / セレブロサイド / セレブロサイドBb / ニトロエタノール / アルドール反応 / α-ハイドロキシパルミチン酸 |
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| Research Abstract |
1. Synthesis of racemic sphingosine 1, the corresponding ceramide 2, and cerebroside 3 and related compounds were accomplished by newly developed our method for synthesis of aminodiols from the reaction of <alpha>,<beta>-unsaturated aldehydes and nitroethanol.
2. As an extension of the above results, the first total synthesis of cerebroside B_<1b>, 4, which was isolated from Tetragonia tetragonoides as a principle withanti-ulcerogenic activity, was succeeded.
3. Optically active <alpha>-hydroxypalmitic acid 6 was synthesized by use of oxazolidinone 5.
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