1987 Fiscal Year Final Research Report Summary
AN INVESRIGATION TO THE EFFECT OF DITERPENOID ON THE BLOOD BRAIN BARRIER
| Project/Area Number |
61571074
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | SETSUNAN UNIV. |
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Principal Investigator |
SAI MIDORI SETSUNAN UNIV.FACULTY OF PHARMACY, 薬学部, 助手 (20170483)
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| Co-Investigator(Kenkyū-buntansha) |
NODE NANABU KYOTO UNIV.INSTITUTE OF CHEMICAL RESEARCH, 化学研究所, 助教授 (60027076)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Rat / mouse Serum cortichosterone / Diterpenoid / Rabdosia trichocarpa Hara / Trichorabdak B and C / 15-oxo-Kaurene / Hydroxylated 15-oxo-Kaurene / Steroidogenic activity (Rat,Mouse) / Serum Corticosterone / Iso lated Rat Adrenal Cells |
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| Research Abstract |
We have been investigating the biological active diterpenoids from dry leaves of Rabdosia trichocarpa Hara,and determined the structuresof Trichorabdal A,B,C,(TA,TB,TC)and other 5 Trichorabdals,and reported the antitumor activity of them.
Now we have found Trichorabdals to suppress the steroid hormone release from isolated rat adrenal cells stimulated with ACTH(ID_<50> 15-50 um).From the the same <alpha>-methylene cyclopentanone system as in antitumour activity,and we synthesized the new suppresser,15-oxohaurenes hydroxylated at C-7,C-9,or C-12.
In vivo activity,TB and17-hydroxykaurene increased serum corticosterone in rat and mous and thisdifferent effect from that of in vitro system may acts through the central nervous system.
Though TB(30mg/kg,ip)had no effect on blood brain barrier becuse of in vivo steroid hormon stmulatory effect,we are investigating the effect of synthetic diterpenoid which suppress the in vivo steroid hormon release.
/Nodosin/15-Oxokaurrene/Hydroxylated 15-Oxokaurene/Steroidogenic actibity
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Research Products
(6 results)
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[Publications] X.HAO,M.NODE,T.TAGA,Y.MIWA,J.ZHOU,S.CHEN,AND K.FUJI: "THE STRUVTURE OF FOUR NWE DITERPNE ALKALOIDS,SPIRAMINES A,B,C,AND D" CHEM.PHARM.BULL.,. 35. 1670-1672 (1987)
Description
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