1987 Fiscal Year Final Research Report Summary
Stuides on the developments of experimantal amnestic models and movel nootropics drugs
| Project/Area Number |
61571101
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
応用薬理学・医療系薬学
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| Research Institution | Meijo University |
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Principal Investigator |
TSUTOMU Kameyama Meijo Unive. Department of chemical pharmacology Faculty of pharmaceutical Science, 薬学部・薬品作用学教室, 教授 (10076698)
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| Co-Investigator(Kenkyū-buntansha) |
MAKOTO Ukai The same as the above, 薬学部・薬品作用学教室, 助手 (80131209)
TOSHITAKA Nabeshima The same as the above, 薬学部・薬品作用学教室, 助教授 (70076751)
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| Project Period (FY) |
1986 – 1987
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| Keywords | Passive avoidance / Mevalonic GABA / Memoty / Nootropics / Amnesia |
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| Research Abstract |
The behaviral pharmacological effects of Ca-4-(3,5-dihydroxy-3-methylpenthylamide) butrate (mevalonic GABA, MV-GABA) a new GABA derivative were studied in compatison with those of Ca-hopantenate (HOPA) in mice. MV-GABA had no effect on the general behavioe and electric shock-induced fighting behavior. The dosage of MV-GABA which caused locomotor hypoactivity induced by a dopamine (DA) agonist (methamphetamine) and acetylcholine (ACh) antagonists (scopolamine and atropine) at a dose which did not affect locomotor activity in normal mice. MV-GABA prolonged the pentobarbital-Na induced sleeping time and it prolonged the latencies until convaision and death after administration of strychnine, MV-GABA and HOPA antagonised the electro-convulisive shock-induced amnesia in the passive avoidance reponse of mice. These results suggest that MB-GABA has effects on the central nervous systems, in particular ACh and DA neural systems. The actions of MV-GABA were qualitatively similar to those of HOPA excepr for the effect on the DA neural system.
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Research Products
(5 results)
