• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1988 Fiscal Year Final Research Report Summary

Development of the heat tolerant rat strain and its hybrids for physiological research of adaptaion

Research Project

Project/Area Number 61870011
Research Category

Grant-in-Aid for Developmental Scientific Research

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionNagoya City University

Principal Investigator

FURUYAMA Fujiya  Nagoya City University Medical School, assistant professor, 医学部, 助手 (00080101)

Project Period (FY) 1986 – 1988
KeywordsInbreds / Rats / Thermoregulation / Development of rat strain / Experimental Animal / Recombinant inbreds / Salive / Salivation / Heat tolerance / Heat resistance
Research Abstract

The present project is consisted of three parts described below.
(1) Development of a heat tolerant rat strain I had already a developing heat tolerant rat colony 3 years ago. Rats in the colony were selected in term of heat tolerance and inbred for further 3 years. The inbred strain has been developed. The inbred strain was most heat tolerant among 20 strains reported in 1982 and 1988. Heat tolerance of F1, F2 and bc between the inbred and ACI rats, which were one of heat intolerant strains, were determined for genetic analyses. Heat tolerance was inherited with polygenic control. Several main genes were suggested to contribute to thermoregulatory mechanisms in a hot environment. It is necessary to purify the inbred for further progress.
(2) Development of hybrids Recombinant inbreds (RI) were established. The most RI were abolished because of temporary poor condition for research in the laboratory. Only one RI was remined and used for development of BC to the heat tolerant inbred. The BC is expected to be used as a control strain. Today, i begin to develop many RI for further progress.
(3) Physiological research on heat tolerance The more heat tolerant the rat strain was, the more actively rats salivated in a hot environment and the higher the body water economics was. Colonic temperature of the heat tolerant rat was 1゜C lower in thermoneutral zone than the existing strains. Colonic temperature also was set near 40゜C in response to acute heat exposure.

  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] F.Furuyama;T.Yoshida;M.Kumazaki;K.Ohara: Jpn.J.Vet.Sci.50. 415-423 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F.Furuyama;Y.Ishida;M.Furuyama;T.Hashitani;Y.Isobe;H.Sato;H.Nishino: Comp.Physiol.Biochem.(1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F.Furuyama;K.ohara: "Genetic adaptaion to hot environment and core temperature in thermoneutral zone.In:Proceedings of International Symposium on Heat stress and heat related-disorders." (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] F.Furuyama;M.Kumazaki;H.Sato;Y.Isobe;T.Ishida;Y.Ishida;H.Nishino: "Significance of thermal dose concept in severity of hyperthermia in conscious rats.In:Proceeding of 5th International Symposium on Hyperthermic Oncology" (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] f. Furuyama; T. Yoshida; M. Kumazaki; K. Ohara: "Thermal salivation and body water economics among Wistar rat strains." Jpn. J. Physiol. Vet. Sci.50. 415-423 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] F. Furuyama; Y. Ishida; M. Furuyama; T. Hashitani; Y. Isobe; H. Sato; H. Nishino: "Thermal salivation in rats anesthetized with barbiturats, chloralose, urethane and ketamine." Comp. Physiol. Biochem.(1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] F. Furuyama; M. Kumazaki; H. Sato; Y. Isoba; T. Ishida; Y. Ishida; H. Nishino.: Sinificance of thermal dose concept in severity of hyperthermia in conscious rats. In: Proceeding of 5th Internation Symposium on Hyperthermic Oncology.(1989)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1990-12-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi