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1990 Fiscal Year Final Research Report Summary

Experimental Investigation on the Cleft Lip and Palate-Research for Preventive Factor of this Disease Using Spontaneous Cleft Lip and Palate Mice Strain

Research Project

Project/Area Number 62440079
Research Category

Grant-in-Aid for General Scientific Research (A)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionAichi-Gakuin University

Principal Investigator

KAWAI Tsuyoshi  Second Department of Oral-Maxillofacial Surgery, School of Dentistry, Aichi-Gakuin University ; Professor, 歯学部・第2口腔外科学教室, 教授 (50064788)

Co-Investigator(Kenkyū-buntansha) NATSUME Nagato  Second Department of Oral-Maxillofacial Surgery, School of Dentistry, Aichi-Gaku, 歯学部・第2口腔外科学教室, 構師 (90183532)
HATTORI Takanori  Second Department of Oral-Maxillofacial Surgery, School of Dentistry, Aichi-Gaku, 歯学部・第2口腔外科学教室, 助教授 (70064813)
Project Period (FY) 1987 – 1990
Keywordscleft lip / cleft palate / preventive factor for cleft lip / preventive factor for cleft palate / spontaneous cleft lip and palate mice strain / whole embryo culture / estradiol / congenital anomaly
Research Abstract

In order to clarify for mechanism of cleft lip and palate and search for preventive factor of cleft lip and palate, we carried out more than 10 animal experiments. We got the result as following papers :
1. Nagato Natsume : Starhylococcus aurers inflammation and cleft palate in mice, plast and reconst. Surg. 85 : 4, 1990
2. Nagato Natsume : Experimental study on cleft lip and palate, II. Induction of cleft palate in ddy mice by carrageenin, J. J. O. M. S. 12(1) : 25-30, 1987
3. Nagato Natsume : Shikaigaku to Shikkan model doubutsu-koushin kougaiertsu shizen hassei mouse-The journal of new dentistry vol. 10(10) : 1-8, 1987
4. Nagato Natsume : Experimental study on cleft lip and palate, IV. Incidence of spontaneous cleft lip and palate in mice (A/J strain) that we are maintaining, J. J. O. M. S. 35(5) : 1194-1197, 1989
5. Nagato Natsume : Experimental study on the cleft lip and palate, V. Induction of cleft palate in Wistar imamichi rats by suspension of dexamethasone, J. J. O. M. S. 35(1) : 80-85, 1989
6. Nagato Natsume : Experimental study on the cleft lip and palate, VI. Induction of cleft palate in Wistar rats by vitamin A, The Aichi-Gakuin Journal of Dental Science Vol. 27, No. 3 : 629-634, September 1989
7. Nagato Natsume : Experimental study on the cleft lip and palate-Role of MMTV (mouse-mammary-tumor-virus) on glucocorticoid induced cleft palate in A/J mice-, J. J. O. M. S. 35(12) : 2819-2826, 1989

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 中村 友保: "A/J系マウス全胚培養法を用いたエストラジオ-ルの口唇裂発生抑制作用の検討" 「日本口腔外科学会雑誌」. 37(2). 351-364 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀内 隆作、夏目 長門、三浦 茂樹、杉本 修一、中村 友保、近藤 定彦、古川 博雄、稲垣 鐘司、生川 哲也、大辻 清、河合 幹: "口唇、口蓋裂発生に関する実験的研究 店9報.口唇、口蓋裂自然発生マウス披裂パタ-ンについて" 「日本口蓋裂学会」. 15. 164-170 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 三浦 茂樹 他: "口唇、口蓋裂発生に関する実験的研究.第7報A/J系マウスにおける自然発現口唇、口蓋裂に対するestradiolの示す抑制作用について" 「日本口蓋裂学会雑誌」. 15(2). 122-131 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河合 幹,夏目 長門: "歯科医に必要な口唇、口蓋裂の基礎知識" デンタルダイヤモンド. 32. 68-73 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 河合 幹,夏目 長門: "口唇、口蓋裂発生機序に関する最近の進歩" 朝日出版社, (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 1. Nagato Natsume: "Stapholococcus aureus inflammation and cleft palate in mice" Plast and reconst. surg. 85. 4 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] 2. Nagato Natsume: "Experimental study on cleft lip and palate, II. Induction of cleft palate in ddy mice by carrageenin" J. J. O. M. S. 12(1). 25-30 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] 3. Nagato Natsume: "Shikaigaku to Shikkan model doubutsu-koushin Kougairetsu shizen hassei mouse" The journal of new dentistry. Vol. 10(10). 1-8 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] 4. Nagato Natsume: "Experimental study on cleft lip and palate, IV. Incidence of spontaneous cleft lip and palate in mice (A/J strain) that we are maintaining" J. J. O. M. S. 35(5). 1194-1197 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] 5. Nagato Natsume: "Experimental study on the cleft lip and palate, V. Induction of cleft palate in Wistar imamichi rats by suspension of dexamethasone" J. J. O. M. S. 35(1). 80-85 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] 6. Nagato Natsume: "Experimental study on the cleft lip and palate, VI. Induction of cleft palate in Wistar rats by vitamin A" The Aichi-Gakuin Journal of Dental Science. Vol. 27, No. 3. 629-634 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] 7. Nagato Natsume: "Experimental study on the cleft lip and palate-Role of MMTV (mouse-mammary-tumor-virus) on glucocorticoid induced cleft palate in A/J mice" J. J. O. M. S. 35(12). 2819-2826 (1989)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-08-12  

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