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1989 Fiscal Year Final Research Report Summary

Interaction of viral and chemical hepatocarcinogenesis

Research Project

Project/Area Number 62480192
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Gastroenterology
Research InstitutionChiba University School of Medicine

Principal Investigator

OMATA Masao  Chiba University, Medical Faculty, Lecturer, 医学部, 講師 (90125914)

Co-Investigator(Kenkyū-buntansha) ITO Yosimi  Chiba University, Medical Faculty, Assistant, 医学部, 助手 (70159929)
IMAZEKI Fumio  Chiba University, Medical Faculty, Fellow, 医学部, 医員
YOKOSUKA Osamu  Chiba University, Medical Faculty, Assistant, 医学部, 助手 (90182691)
Project Period (FY) 1987 – 1989
KeywordsDHBV / Oncogenesis / Aflatoxin / Integration of DHBV / HCC
Research Abstract

We have elucidated the following in the study of interaction of viral and chemical hepatocarcinogenesis.
A) We have established an model from duck hepatitis B virus (DHBV) infection to hepatocarcinogenesis.
B) In viral oncogenesis, the development of hepatocellular carcinoma was observed after 3 years of infection. DHBV DNA was integrated in the majority of the tumor.
C) In chemical oncogenesis, the development of hepatocellular carcinoma was observed in one to two years, somewhat earlier thail viral oncogenesis.
C) In viral and chemical oncogenesis combined, the development of the tumor was observed in one to two years, similar to chemical carcinogenesis.
However, integration of DHBV DNA was not observed in any of the tumors.
In conclusion, viral and chemical oncogenesis seems to have different pathway of development of hepatocellular carcinoma. Integration of DHBV into host genome may be prerequisite for virus related oncogenesis.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Imazeki F,Yaginuma K,Omata M,Okuda K,Kobayashi M,Koike K: "RNA transcrspts of hepatitis B virus in hepatocellulan cercinoma" Hepatology. 7. 753-757 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Omata M: "Hepatitis B virus DNA antigen and liver pathology in ducks:an animal model of human liver diseese" In:Hepadna Viruses.UCLA Symposia on Melecwlar and Cailular Biology. 349-356 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Imazeki F,Yaginuma K,Omata M,Okuda K,Kobayashi M,Koike K: "Integrated structures of duck hepatitis virus DNA in hepatocellalar carcinoma" J Virology. 62. 861-865 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Omata M: "Liver diseases associated with Hepadna virus intection.A study in duck model" Cancer Detection and Prevention. 14. 231-233 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小俣政男: "Duck hepatitis B virusと肝発がん" Biomedica. 4. 31-34 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Omata M: "Neoplasms of The Liver「Hepadna Virus and Hepatocarcinogenesis」" Springer-Verlag,Tokyo, 35-45 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小俣政男,今関文夫: "HBV-DNA組み込みと発癌" 「肝炎」鈴木宏編,東京,南江堂, 259-263 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Imazeki F, Yaginuma K, Omata M, Okuda K, Kobayashi M, Koike K: "RNA transcripts of hepatitis B virus in hepatocellular carcinoma." Hepatology 7:753-757, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Omata M.: "Hepatitis B virus DNA, antigen and liver pathology in ducks: an animal model of human liver disease" In: Hepadna Viruses. UCLA Symposia on Molecular and Cellular Biology. pp349-356, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Imazeki F, Yaginuma K, Omata M, Okuda K, Kobayashi M, Koike K.: "Integrated structures of duck hepatitis virus DNA in hepatocellular carcinoma." J Virology 62: 861-865, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Omata M.: "Liver diseases associated with Hepadna virus infection. A study in duck model." Cancer Detection and Prevention 14: 231-233, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Omata M.: "Hepadna Virus and Hepatocarcinogenesis" In: Neoplasms of The Liver. Springer-Verlag, pp35-45, 1987.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-26  

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