1989 Fiscal Year Final Research Report Summary
Research of Clinical Features and Pathomechanism of HAM
| Project/Area Number |
62480208
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Kagoshima University |
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Principal Investigator |
OSAME Mitsuhiro Kagoshima University, Faculty of Medicine, Professor, 医学部, 教授 (10041435)
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| Co-Investigator(Kenkyū-buntansha) |
IGATA Akihiro Kagoshima University, President, 学長 (00010207)
IZUMO Shuji Kagoshima University, Faculty of Medicine, Lecturer, 医学部, 講師 (30143811)
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| Project Period (FY) |
1987 – 1989
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| Keywords | HTLV-I / HAM / TSP / Treatment / Blood Transfusion / Epidemiology / Clincal / HTLV-I Associated Myelopathy |
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| Research Abstract |
We could establish the clinical entity of HTLV-I-associated nmyelopathy(HAM). The nationwide survay of HAM was performed and 710 patients of HAM were found to exist throughout Japan. More than 60% of them were living in Kyushu. About 26% of the patients had the previous history of blood transfusion. Clinical features were analyzed. Immunological studies were also done and activated T lymphocytes were found to be increased both in serum and CSF. Electroencephalographic abnormalities were also found in HAM. Three patients were autopsied and detailed neuropathological analysis were done. The main lesions existed at the thorathic level of the spinal cord and were consisted of inflammatory mononuclear cell infiltration around vessels and gliosis. Immunosupressive treatment were found to be effective for HAM.
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