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1989 Fiscal Year Final Research Report Summary

Analysis of TSH receptor antibody and studies of effects of it upon thyroid development and function.

Research Project

Project/Area Number 62480223
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionHokkaido University

Principal Investigator

MATSUURA Nobuo  Hokkaido University School of Medicine, Associate Professor, 医学部, 助教授 (50002332)

Co-Investigator(Kenkyū-buntansha) FUJIEDA Kenji  Hokkaido University Medical Hospital, Instructor, 医学部附病院, 助手 (60173407)
Project Period (FY) 1987 – 1989
KeywordsTSH-receptor antibody / TSH-binding inhibitor immunoglobulin(TBII) / Thyroid stimulating antibody (TSAb) / Thyroid-stimulation blocking antibody(TSBAb) / Cretinism / Graves' disease / Atrophic autoimmune thyroiditis(AAT) / Goitrous autoimmune thyroiditis(GAT)
Research Abstract

1. We were distributed rat thyroid FRTL-5 cell from Dr. Kohn of NIH and using FRTL-5 cell , we have established the methods for detection of TSH-receptor antibody activities, that is, TSH-binding inhibitor immunoglobulins(TBII),Thyroid-stimulating antibody(TSAb),Thyroid-stimulation blocking antibody(TSBAb),antibody which inhibit iodine transport or thysidine incorporation into FRTL"5 cells. We have determined these activities in patients with various auto-immune thyroid diseases to find out any etiological significance of the diseases.
1) Chronic thyroiditis: We couldn't detected TSH-receptor blocking antibodies(TBII and TSBAB) in patients with atrophic autoinsune thyroiditis(AAT) of childhood onset which suggested the pathogenesis of AAT in childhood is different from that of postpubertal onset. It is well known that mother who possessed TSH-receptor blocking antibody give birth hypothyroid infant however,the correlation between mother's TSH-receptor blocking antibody activities and ou … More tcome of their offspring have not fully elucidated. We have established the method to predict thyroid dysfunction of newborn infants with diluting mother's serum with normal pooled serum to obtained 50% inhibition of labeled TSH binding to its receptor which enable us to prenatal diagnosis of hypothyroidism and ultra-early start of treatment.
2) Graves' disease: Both TBII and TSAB antibody activity were detected at diagnosis and these activities were decreased with anti-thyroid treatment. We have evaluated these activity.whether it might be a good indicator of long-term prognosis of Grave's disease and found that TSAB is the most useful indicator of remission or relapse of the disease. To elucidate the relationship between the mother's TSH-receptor antibody activities and the status of thyroid dysfunction in their offspring, We have studies TSII and TSAB activities in mother's sera. We found that TBII and TSAB activities were responsible for development neonatal thyrotoxicosis, while on the other hand very weak TSAB activities regardless of TBII were detected in mothers who gave birth infants with transient hypothyroxinemia which is a new thyroid dysfunction proposed by us.
3) Cretinism: It was reported that there are some autoantibodies in mothers who gave birth sporadic cretinism. We have evaluated TSH-receptor blocking antibody and antibodies which inhibit iodine transport or thysidine incorporation into DNA using FRTL-5 cell, however, we could not found any difference between normal controls.
2. Neonatal screening for congenital hypothyroidism: More than ten years has passed since we start screening for congenital hypothyroidism. Nationwide study of mental development was performed and found there is a significant difference between normal control and cretinism who were over 6 years of age. It is necessary to continue future evaluation and improvement of treatment.
We have conducted population-basis study of cretinism in Hokkaido and reported the incidence and types of disease. We also evaluated iodine metabolism in prenatal period to improve sensitivity and accuracy of screening. Less

  • Research Products

    (58 results)

All Other

All Publications (58 results)

  • [Publications] 福士勝: "乾燥3紙血液の遊離サイロキシン及び遊離トリョ-ドサイロニンの測定と新生児甲状腺機能スクリ-ニングへの応用" 日本小児科学会雑誌. 91. 5-11 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松浦信夫: "バセドウ病母親のTSH受容体抗体と児の予後" 医学のあゆみ. 140. 109-110 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤枝憲二: "高感度TSH測定法(IRMA法)の小児科領域への臨床的検討" ホルモンと臨床. 35. 839-843 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松浦信夫: "抗レセプタ-抗体による新生児疾患" 日本臨床免疫学会雑誌. 10. 480-483 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuo Natsuura: "TSH-receptor antibodies in mothers with Graves' disease and outcome in thier offspring" Lancet. I. 14-17 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 由利賢次: "バセドウ病の母親から生まれた新生児にみられる一過性低TS_4血症" ホルモンと臨床. 36. 671-675 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松浦信夫: "小児のバセドウ病" Medical Practis. 5. 1147-1149 (1988)

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      「研究成果報告書概要(和文)」より
  • [Publications] 原田正平: "心身障害を残さないクレチン症の治療" 小児科診療. 51. 802-806 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松浦信夫: "母体と新生児の甲状腺機能" 小児科診療. 51. 2474-2480 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuo Matsubara: "The prediction of thyroid function in infants born to mothers with chronic thyroiditis." Endocrinologia,Japonica. 36. 865-871 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 由利賢次: "内分泌検査法(2)-甲状腺系-" 小児科診療. 52. 192-198 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 原田正平: "新生児のスクリ-ニング-甲状腺機能低下症-" 周産期医学. 19. 669-672 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石黒信久: "抗けいれん剤長期服用が甲状腺ホルモンに及ぼす影響について" 小児科臨床. 41. 2045-2050 (1988)

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      「研究成果報告書概要(和文)」より
  • [Publications] 原田正平: "北海道(札幌市を除く)におけるクレチン症マス・スクリ-ニング" 臨床小児医学. 37. 171-178 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] 柴田睦郎: "急性化膿性甲状腺炎の2例" 小児外科. 21. 938-940 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] 中島博徳: "マス・スクリ-ニングで発見された先天性甲状腺機能低下患者における神神経学的予後全国調査成績" 日本小児科学会雑誌. 93. 2011-2016 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] 原田正平: "札幌市におけるTSH-T_4測定によるクレチン症マス・スクリ-ニング" 日本小児科学会雑誌. 93. 2742-2749 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuo Matsubara: "Comparison of atrophic and goitrous autoimmune thyroiditis in children:Clinical,laboratory and TSH-receptor antibody studies." Europian J.of Pediatrics accepted for publication.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuo Matsubara: "Transient hypothyroidism in infants born to mothers with chronic thyroiditis-A nationwide studies of twenty-three cases." Endocrinologia Japonica.accepted for publication. (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kenji Yuri: "Transient hypothyroxinemia in infants born to mothers with poorly controlled Graves' disease" Pediatric Reserch.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 原田正平: "クレチン症マス・スクリ-ニングで精検対象となり異常なしと判定された児の予後の検討" 日本小児科学会雑誌.

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      「研究成果報告書概要(和文)」より
  • [Publications] 原田正平: "抗甲状腺剤治療後に甲状腺機能低下症に移行した小児期バセドウ氏病患者の病因の検討" 日本小児科学会雑誌.

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      「研究成果報告書概要(和文)」より
  • [Publications] 原田正平: "阻害型YSH受容体抗体による新生児一過性甲状腺機能低下症の出生前診断" ホルモンと臨床.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuo Matsubara: "Transient hypothyroidism in the newborn infant--A nation-wide study.Advances in neonatal screening.BL Therrell Jr edited." Excerpta Medica, p49-52 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuo Matsubara: "Transient hypothyroidism in infants due to maternal TSH-receptor blocking antibodies.Charactor of their IgG and longterm prognosis of their infants.in Reserch in congenital hypothyroidism.DeLange F,Fisher DA,Glinoer D edited" Plenum Press, p111-122 (1989)

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      「研究成果報告書概要(和文)」より
  • [Publications] Nobuo Matsubara: "TSH-receptor antibodies in mothers with autommnune thyroid disease and outcome in their offspring.in Progress in Thyroidology 1989.M Lee,C-S Koh,J Eastman,S Nagataki edited" Korea Medical Publishing Company, p123-126 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masaru Fukushi: "A pilot study on screening for thyroid function in early pregnancy by using dried blood spots.in Progress in Thyroidolgy 1989.M Lee,C-S Koh,Eastman J,S Nagataki,edited" Korea Medical Publishing company, p379-382 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuo Matsubara: "TSH-receptor antibodies in mothers with autommune thyroid disease and outcome in their offspring.Endocrine Chronobiology,edited by Tsutomu Hiroshige." Hokkaido University Press, (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nobuo Matsubara: "The role of TSH-receptor blocking antibodies in congenital hypothyroidism" Elsevier Scientific Publishers, (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushi M: "Measurements of free thyroxine and free triiodothyronine in dried blood on filter paper and its application to neonatal thyroid screening." J Jpn Pediatr Soci 91:5-11, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: "TSH receptor antibodies in mothers with Graves' disease and outcome of their offspring." Igaku no ayumi 140:109-110, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujieda K: "Clinical studies on measurement of serum TSH concentration in children using highly sensitive TSH immunoradiometricassay." Clin Endocrinol 35:839-843, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: "Anti-receptor antibody and neonatal disease." Jpn J Clin Immun 10:480-483, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: "TSH-receptor antibodies in mothers with Graves' disease mothers with Graves' disease and outcome in their offspring." Lanet I:14-17, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuri K: "Transient hypothyroxinemia in infants born to mothers with Graves' disease." Clin Endocrinol 36:671-675, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: "Graves' disease in children." Medical Practis 5:1147-1149, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harada S: "Treatment of cretinism not to leave any handicap." J Pediatr Prac 51:802-806, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: "Thyroid function in the mothers and their infants." J Pediatr Prac 51:2474-2480, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: "The prediction of thyroid function in infants born to mothers with chronic thyroiditis." Endocrinol Japon 36:865-871, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuri K: "Endocrine function test-Thyroid function-" J Pediatric Prac 52:192-198, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harada S: "Neonatal screening-Congenital hypothyroidism-" Prenatal Medicine 19:669-672, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishiguro N: "Effects of longterm administration of anti-convulsants upon serum thyroid hormone levels." Jpn J Pediatr 41:2045-2050, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harada S: "Neonatal screening for congenital hypothyroidism in Hokkaido(excluding city of Sapporo)." J Clin Pediatr 37:171-178, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shibata M: "Two cases of acute suppurative thyroiditis." Jpn J Pediatr Surg 21:938-940, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakajima H: "National study of mental development with congenital hypothyroidism disclosed by neonatal screeing in Japan." J Japan Pediatr Soci 93:2011-16, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harada S: "Neonatal screening for congenital hypothyroidism by simultaneous assay of TSH and T_4 in Sapporo." J Japan Pediatr Soci 93:2742-49, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: "Comparison of atrophic and goitrous auto-immune thyroiditis in children: clinical, laboratory and TSH-receptor antibody studies." Eur J Pediatr:1990.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: "Transient hypothyroidism in infants born to mothers with chronic thyroiditis- A nationwide study of twenty-three cases-" Endocrinol Japon:1990.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yuri K: "Transient hypothyroxinemia in infants born to mothers with poorly controlled Graves' disease." Pediatr Research.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harada S: "Longterm prognosis of infants who were once detected by neonatal thyroid screening and were regarded as normal." J Jpn Pediatr Soci.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harada S: "The pathogenesis of hypothyroidism after antithyroid drug treatment in patients with Graves' disease." J Jpn Pediatr Soci.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Harada S: "Prenatal diagnosis of neonatal transient hypothyroidism due to maternal TSH-receptor blocking antibodies." Clin Endocrinol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: Transient hypothyroidism in the newborn infants- A nationwide study. Advances in neonatal screening. BL Therrell Jr. edited. Excerpta Medica, 49-52 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: Transient hypothyroidism in infants due to maternal TSH-receptor blocking antibodies Character of their egg and longterm prognosis of their infants. Research in congenital hypothyroidism. F Delange, DA Fisher, D Glinoer edited.Plenum Press, 111-122 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: TSH-receptor antibodies in mothers with autoimmune thyroid diseases and outcome in their offspring. Progress in Thyroidology 1989. M Lee, C-S Koh, J Eastman, S Nagataki edited. Korea Medical Publishing Company, 123-126 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushi M: A pilot study on screening for thyroid function in early pregnancy by using dried blood spots. Progress in Thyroidology 1989. M Lee, C-S Koh, J Eastman, S Nagataki edited. Korea Medical Publishing Company, 379-382 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: TSH-receptor antibodies in mothers with autoimmune thyroid disease and outcome in their offspring. Endocrine chronobiology, Tsutomu Hiroshige edited.Hokkaido University Press, (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuura N: The role of TSH-receptor blocking antibodies in congenital hypothyroidism. HA Drexhage, WM Wiersinga, JJM de Vijlder edited.Elservier Scientific Publishers, (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-26  

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