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1989 Fiscal Year Final Research Report Summary

Experimental Study on Neuronal Plasticity after Damage in Developing Brain.

Research Project

Project/Area Number 62480227
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionShiga University of Medical Science

Principal Investigator

SHIMADA Morimi  Shiga University of Medical Science, Department of Pediatrics, Professor., 医学部, 教授 (00079873)

Co-Investigator(Kenkyū-buntansha) YAMAMOTO Hisashi  Shiga University of Medical Science, Pediatrics Ex-Junior lecturer, 医学部, 助手 (20174807)
OHNO Masaki  Shiga University of Medical Science, Pediatrics Junior lecturer, 医学部, 助手 (50194254)
KAWASAKI Hisaki  Shiga University of Medical Science, Pediatrics Ex-Junior lecturer (00177669)
Project Period (FY) 1987 – 1989
KeywordsNeuronal plasticity / Cerebral damage / Developing brain / Corticospinal tract
Research Abstract

The right cerebral cortex of l-, 7-, 14-, 28- and 56-day-old rats was ablated by electrical coaguration. After 2 to 3 months of operation, the cerebrum, pons and spinal cord of these rats were examined histologically and histochemically using the retrograde and antegrade horse radish peroxidase(HRP) method. The left corticospinal tract at the posterior funiculus in the spinal cord showed severe atrophy. However, left corticospinal tract in the spinal cord of 2-months-old rat, which had had neonatal operation, showed considerable increase in small myelinated fibres.
The retrograde HRP examination for normal adult rats in which HRP had been injected into left cervical cord, demonstrated a number of HRP positive neurons to be localized at the 5th layer of the right cerebral cortex. Whereas, in the neonatally operated rats, which had HRP injection into left cervical cord, a few HRP positive neurons were found at the 5th layer of ipsilateral left cerebral cortex. However, HRP positive neurons were not found in the left cerebral cortex of the rat which had had an electrical ablation of the right cerebral cortex after 4 weeks of age.
When HRP was injected into the left sensori-motor cortex of normal adult rats and HRP positive fibers were retrogradly traced, all of the HRP positive fibers crossed over the pyramidal decussation to reach the right posterior funiculus where the corticospinal tract fibers concentrated. At the pyramidal decussation of 2- and 3-months-old rats, which had had right cortical ablation on postnatal days 1, 7, or 14 , a few HRP positive fibers were noticed extending to the right posterior funiculus without crossing over. These ipsilateral corticospinal fibers were more in number in the neonatally operated rat. Very few HRP positive ipsilateral fibers were found in the rats operated on 28 days of age, but were not in adultly operated rats.

  • Research Products

    (33 results)

All Other

All Publications (33 results)

  • [Publications] Tsunekazu Yamano,Morimi Shimada,Hisaki Kawasaki,Akira Onaga,et al.: "Clinico-pathological study on macular mutant mouse." Acta Neuropathologica(Berl). 72. 256-260 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisaki Kawasaki,Akira Onaga,Tsunekazu Yamano,Morimi Shimada,et al.: "Golgi study on brain of macular mutant mouse as a model of Menkes kinky hair disease." Acta Neuropathol(Berl). 72. 349-354 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akira Onaga,Hisaki Kawasaki,Tsunekazu Yamano,Morimi Shimada,et al.: "Light and electron microscopic study on cerebellar cortex of macular mutant mouse as a model of Menkes kinky hair disease." Brain&Development. 9. 265-269 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akiko Sasahara,Shousaku Yamasaki,Toshiharu Tachiiri,Hisaki Kawasaki,et al: "Biochemical study on the brain of the macular mutant mouse as a model of menkes kinky hair disease." Brian&Development. 0. 54-56 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsunekazu Yamano,Morimi Shimada,Akira Onaga,Hisaki Kawasaki,et al.: "Electron microscopic study on brain of macular mutant mouse after copper therapy." Acta Neuropathologica(Berl). 76. 574-580 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hisaki Kawasaki,Tsunekazu Yamano,Satoru Iwane,Morimi Shimada: "Golgi study on macular mutant mouse after copper therapy." Acta Neuropathologica(Berl). 76. 606-612 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morimi Shimada: "Congenital Anomalies of Central Nervous System and Neuronal Plasticity." Congenital Anomalies. 29. 31-40 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satoru Iwane,Hisaki Kawasaki,Tsunekazu Yamano,Morimi Shimada: "Golgi study on the Homozygote(M1/M1) of Macular mutant mouse." Brain&Development. 11. 154-160 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kyokazu Ono,Morimi Shimada,Tsunekazu Yamano: "Reorganization of the Corticospinal Tract Following Neonatal Unilateral Cortical Ablation in Rats." Brain&Development(in press). 12. (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田中和彦,鳴戸敏幸,山本尚,西澤嘉四郎,立入利晴,奥村啓子,島田司巳: "Phenytoinが胎仔発育に及ぼす影響に関する実験的研究 I.Phenytoinおよび代謝産物の胎盤通過性について" 脳と発達. 20. 363-367 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田中和彦,鳴戸敏幸,山本尚,西澤嘉四郎,立入利晴,奥村啓子,島田司巳: "Phenytoinが胎仔発育に及ぼす影響に関する実験的研究 II.Phenytoinの胎盤移行と胎仔発育" 脳と発達. 20. 368-372 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田中和彦,鳴戸敏幸,山本尚,西澤嘉四郎,立入利晴,奥村啓子,島田司巳: "Phenytoinが胎仔発育に及ぼす影響に関する実験的研究 III.生後の脳発育に及ぼす影響について" 脳と発達. 20. 373-378 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 島田司巳,西澤嘉四郎,翁長晃: "脳発達障害の成因と形態異常" 小児科診療. 51. 2274-2280 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 島田司巳,山野恒一,大野雅樹,山崎正策: "脳発達障害の成因と形態学的基礎" 神経研究の進歩. 32. 924-935 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山野恒一,島田司巳: "シナプス形成とその異常" 神経研究の進歩. 33. 484-494 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 西澤嘉四郎,田中和彦,島田司巳: "新生児低酸素性・虚血性脳障害に関する実験的研究 I.組織学的変化について" 脳と発達(in press). 22. (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 西澤嘉四郎,田中和彦,島田司巳: "新生児低酸素性・虚血性脳障害に関する実験的研究 II.代謝面の変化について" 脳と発達(in press). 22. (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 島田司巳: "小児医学20 中枢神経発達と可塑性" 医学書院, 11 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 島田司巳,山崎正策: "小児科MOOK 50 新生児の神経病 栄養と神経系の発達障害" 金原出版, 12 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsunekazu Yamano, et al.: "Clinico-pathological study on macular mutant mouse." Acta Neuropathol. (Berl), 72:256-260, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisaki Kawasaki, et al.: "Golgi study on brain of macular mutant mouse as a model of Menkes kinky hair disease." Acta Neuropathol. (Berl), 72:349-354, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akira Onaga, et al.: "Light and electron microscopic study on cerebellar cortex of macular mutant mouse as a model of Menkes kinky hair disease." Brain & Development 9:265-269, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsunekazu Yamano, et al.: "Electron microscopic study on brain of macular mutant mouse after copper therapy." Acta Neuropathol. (Berl). 76:574-580.1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hisaki Kawasaki, et al.: "Golgi study on macular mutant mouse after copper therapy." Acta Neuropathol. (Berl). 76:606-612, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morimi Shimada.: "Congenital anomalies of central nervous system and neuronal plasticity." Congenital Anomalies 29:31-40, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Satoru Iwane, et al.: "Golgi study on the homozygote (Ml/Ml) of macular mutant mouse." Brain & Development 11:154-160, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kyokazu Ono, et al.: "Reorganization of the corticospinal tract following neonatal unilateral cortical ablation in rats." Brain & Development 12, 1990.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morimi Shimada.: "Development of Central Nervous System and Neuronal Plasticity. (in Japanese)." Child Medicine 20:888-898, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morimi Shimada, et al.: "Nutrition and Development of Nervous System. (in Japanese)." Pediatric Mook 50:239-250, 1987.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morimi Shimada, et al.: "Pathogenesis of developmental disorders of brain. (in Japanese)." Pediatric Practice 51:2274-2280, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morimi Shimada, et al.: "Morphological basis on pathogenesis of developmental disorders of brain. (in Japanese)." Shinkei Kenkyuu no Shinpo 32:924-935, 1988.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsunekazu Yamano, et al.: "Synaptic formation and its abnormalities. (in Japanese)." ibid 33:484-494, 1989.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kashiro Nishizawa, et al.: "Experimental study on neonatal hypoxuc-ischemic encephalopathy. (in Japanese)." Nou to Hattatsu 22: 1990.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-26  

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