1989 Fiscal Year Final Research Report Summary
Action mechanism of the regulatory factors in oocyte maturation and embryo growth
| Project/Area Number |
62480350
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | NIHON UNIVERSITY (1989)
Saitama Medical University (1987-1988) |
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Principal Investigator |
SATOH Kazuo PROFESSOR DEPARTMENT OF OBSTETRICS & GYNECOLOGY, NIHON UNIVERSITY SCHOOL OF MEDICINE, 医学部・産婦人科, 教授 (80010180)
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Toshiyuki ASSISTANT PROFESSOR DEPARTMENT OF OBSTETRICS & GYNECOLOGY, SAITAMA MEDICAL CENTE, 産婦人科, 講師 (90153535)
TAKEDA Satoru ASSISTANT PROFESSOR DEPARTMENT OF OBSTETRICS & GYNECOLOGY, SAITAMA MEDICAL CENTE, 産婦人科, 講師 (20143456)
KINOSHITA Katsuyuki ASSOCIATE PROFESSOR DEPARTMENT OF OBSTETRICS & GYNECOLOGY, SAITAMA MEDICAL CENTE, 産婦人科, 助教授 (80010354)
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| Project Period (FY) |
1987 – 1989
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| Keywords | Oocyte / Oocyte maturation / Prostaglandin / Fertilized egg / Progesterone / Hexokinase |
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| Research Abstract |
Action mechanism of prostaglandin (PG) on oocyte maturation was investigated. PG was shown to act on oocyte maturation as an intermediate by blocking transfer of oocyte maturation inhibitors into oocyte directly and/or indirectly.
Mouse fertilized eggs were able to produce progesterone by themselves. Progesterone so produced was transferred into the nucleus and activated transcription of DNA coding hexokinase to MRNA with a resultant increase in hexokinase activity in embryos.
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