1988 Fiscal Year Final Research Report Summary
Synthesis of Platinum Complexes Coordinated by Sulfur Containing Compounds and their Anticancer Mechanism
| Project/Area Number |
62550555
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
無機工業化学
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| Research Institution | Saitama University |
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Principal Investigator |
TAKEAKI IIDA Professor, Faculty of Engineering, Saitama University, 工学部, 教授 (30013171)
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| Co-Investigator(Kenkyū-buntansha) |
KOICHI NISHIGAKI Assistant Professor, Faculty of Engineering, Saitama University, 工学部, 助教授 (10107378)
AKIRA MIYASHITA Assistant Professor, Faculty of Engineering, Saitama University, 工学部, 助教授 (90132729)
TAKASHI MITAMURA Professor, Faculty of Engineering, Saitama University, 工学部, 教授 (50008827)
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| Project Period (FY) |
1987 – 1988
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| Keywords | Platinum Complex / Anticancer Activity / Sulfur Containing Ligand / 担体配位子 |
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| Research Abstract |
Cis-diamminedichloroplatinum (II) complex (cis-DDP) is widely utilized as an anticancer agent for clinical treatments of various cancers. It has been confirmed by many evidences that cis-DDP binds specifically with DNA in cancer cells to inhibit the replication of the DNA. Therefore, many investigations concerning novel platinum complexes with various carrier ligands have been developed to be used as anticancer agents. However, the study on the platinum complex coordinated with a ligand containing sulfur atoms has not been reported yet. in this paper, a novel platinum complex, dichloro-2-aminoethylsulfonyl-platinum (II), was synthesized. The structure of the platinum complex was analyzed by IR and ^<13>C-NMR spectra, elementary analysis and atomic absorption spectrophotometry. The investigations were also carried out on the interaction between the platinum complex and DNA constituent nucleosides by analyzing the UV difference spectra and the liberation rate of the chloride ions from the platinum complex. The isosbestic points were observed in the UV difference spectra for the platinum complex-nucleoside system. It was also found that two chloride ions were liberated from the platinum complex in the interaction with the nucleosides. The platinum complex was found to exhibit a specific anticancer activity against adriamycin resistant cancer cells.
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