1989 Fiscal Year Final Research Report Summary
pathophysiology and treatment of congestive heart failure; role of atrial natriuretic peptide
| Project/Area Number |
62570438
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | School of Medicine, Keio University |
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Principal Investigator |
MORIKAWA Yoshiyuki Keio Univ. Dept. of Pediatrics, assistant Professor, 医学部・小児科, 講師 (60101979)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIHARA Jun Keio Univ. Dept. of Pediatrics, instructor, 医学部・小児科, 助手 (50146635)
KOMIYAMA Osamu Keio Univ. Dept. of Pediatrics, instructor, 医学部・小児科, 助手 (70162063)
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| Project Period (FY) |
1987 – 1989
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| Keywords | atrial natriuretic peptide / congestive heart failure / renal function |
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| Research Abstract |
Atrial natriuretic peptide (ANP) plays an important role on the control of fluid balance. Although blood ANP concentration is elevated in congestive heart failure (CHF), its pathophysiologic features and its usefulness as a therapeutic mode of CHF is not fully understood. An experimental canine model of CHF was prepared by anastomosis of abdominal aorta and inferior vena cava. The effect of ANP on blood pressure, renal fraction, and renin aldosterone system was evaluated in the CHF and control dogs. In the control group, blood pressure and pulse rate were decreased in response to ANP. Urine volume, FENa, and FEC1 were increased. There was no significant changes in FEK, GFR, and RPF. In the CHF group, GFR was lower, and plasma renin activity and aldosterone level were higher than the control. Blood ANP concentration was slightly elevated in the CHF group. The effect of ANP on blood pressure Pulse rate , urine volume, FENa, and FECl were attenuated in CHF. The attenuated response of renal functim to ANP may be due to down regulation of ANP receptor, accelerated renin aldosterone system, or the effect on renal symthetic activity. The therapeutic role of ANP in CHF as a diuretic is doubtful. The vasodilating effect of ANP may be beneficial in the treatment of CHF.
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