1988 Fiscal Year Final Research Report Summary
Contractile system of the heart in the early development
| Project/Area Number |
62570440
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Tokyo Women's Medical College |
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Principal Investigator |
NAKANISHI Toshio Tokyo Women's Medical College, 循環器小児科, 講師 (90120013)
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| Co-Investigator(Kenkyū-buntansha) |
SEGUCHI Masashi Tokyo Women's Medical College (50192141)
TAKAO Atsuyoshi Tokyo Women's Medical College (70075167)
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| Project Period (FY) |
1987 – 1988
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| Keywords | Calcium / Myocardium / Fetus / Newborn / 胎仔 |
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| Research Abstract |
Contractile system of the fetal heart was evaluated. 1) Mechanical function: contractile function was measured and the study showed that the contractile force in the early f etos is less than in the newborn. Myocardial contraction in the fetus is dependent on the extracellular calcium rather than on the calcium released from the intracellular store site. 2) Ultrastructure: electron microscopy revealed that myofibrils are scarce in the fetus and there is no sarcoplasmio reticulum in the early fetus. 3) Intracellular calcium concentration: microspectroscopic examination showed that intracellular calcium concentration in the early fetus is higher than in the newborn.
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