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1988 Fiscal Year Final Research Report Summary

CHANGE IN MYOSIN HEAVY CHAIN IN PULMONARY ARTERY-BANDED AND DEBANDED RAT HEART

Research Project

Project/Area Number 62570442
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionHEART INSTITULE OF JAPAN, TOKYO WOMEN'S MEDICAL COLLEGE

Principal Investigator

MATSUOKA Rumiko  DEPT. OF PEDIATRIC CARDIOLOGY, HEART INSTITUTE OF JAPAN・RESEARCH ASSOCIATE, 循環器小児科, 助手 (50120051)

Co-Investigator(Kenkyū-buntansha) TAKAO Atsuyoshi  DEPT. OF PEDIATRIC CARDIOLOGY, HEART INSTITATE OF JAPAN・PROFESSOR (70075167)
IMAMURA Shin-ichiro  RESEARCH DIVISION, HEART INSTITUTE OF JAPAN・RESEARCH ASSOCIATE (00176497)
KIMURA Misa  DEPT. OF PEDIATRIC CARDIOLOGY, HEART INSTITUTE OF JAPAN・RESEARCH ASSOCIATE (60192019)
Project Period (FY) 1987 – 1988
KeywordsCARDIAC MYOSIN / MYOSIN GENE / CONTRACTILE PROTEIN / 肺動脈絞扼
Research Abstract

It has been shown that the distribution of cardiac myosin heavy chain (MHC) isozymes is regulated during development by hemodynamic change and hormonal stimuli and this transition is mainly regulated by pretranslational mechanisms. To study whether the changes in MHC gene expression produced by left-sided overload are limited to the left ventricle (LV) or extend to the right ventricle (RV), or whether right-sided overload are limited to RV or extends to LV, we examined the MHC gene expression and isozyme transition. For these studies, pulmonary artery-banded (PAB) rats and sham-operated rats were prepared. These data were compared with previous study on aortic coarctated (CoA) rats. Results : There was no significant differences of peak-systolic pressure, wall thickness, V3-MHC and -MHC in RV of the CoA rats and in LV of the PAB rats compared with shzm-operated rats, while significant induction of them in LV of the CoA rats and in the RV of PAB rats. These animals showed both ventricular end-diastolic pressure were within the normal range. Conclusions : We found that the changes in the MHC gene expression and isozyme produced by one-sided ventricular overload are limited to the involved ventricle and do not extend to the other one. In this study, it is suggested that MHC gene regulation during pressure overload may not be induced by intrinsic factors, such as hormone or catecholamine or ANP, but is induced by direct local response to increased load.

  • Research Products

    (24 results)

All Other

All Publications (24 results)

  • [Publications] Matsuoka,R.: Am.J.Med.Gen.29. 369-376 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松岡瑠美子: 東京女子医科大学雑誌. 58. 73-82 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Imamura,S.: Circulation. 78. 59 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuoka,R.: Am.J.Med.Gen.32. 279-284 (1989)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松岡瑠美子: Jpn.Circ.J. (抄録).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 今村伸一郎: Jpn.Circ.J. (抄録).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松岡瑠美子: 62年度業績集日本心臓血圧振興会. 発刊予定.

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      「研究成果報告書概要(和文)」より
  • [Publications] Izumo,S.: J.Clin,Invest.79. 970-977 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松岡瑠美子: 61年度業績集 日本心臓血圧研究振興会. 20-23 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松岡瑠美子: "小児心臓病学、心筋の発達、ミオシン重鎖の分子生物学的研究" 中外医学社,

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Imamura,S.: "Adaptational changes of myosin heavy chain gene expressions and isozyme transitions in cardiac overloading.In:Etiology and morphogenesis of congenital heart disease." Futura,

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松岡瑠美子: "小児医学 小児循環器病学の進歩、発達心臓病学、1) ミオシン重鎖遺伝子の発現と発達" 医学書院, 18 (1987)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] MATSUOKA, R.: "MOLECULAR CLONING AND CHROMOSOMAL LOCALIZATION OF A GENE CODING FOR HUMAN CARDIAC MYOSIN HEAVY-CHAIN." AM.J.MED.GEN.29. 369-376 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MATSUOKA, R.: "MOLECULAR CLONING AND CHROMOSOMAL LOCALIZATION OF A GENE CODING FOR HUMAN CARDIAC MYOSIN HEAVY CHAIN." J.TOKYO WOMEN'S MEDICAL COLLEGE.58. 73-82 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] IMAMURA, S.: "LOCAL RESPONSE TO CARDIAC OVERLOAD ON MYOSIN HEAVY CHAIN GENE EXPRESSION AND ISOZYME TRANSITION." CIRCULATION. 78. 59 (1988)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MATSUOKA, R.: "HUMAN CARDIAC MYOSIN HEAVY CHAIN GENE MAPPED WITHIN CHROMOSOME REGION 14q11.2-q13" AM.J.MED.GEN.32. 279-284 (1989)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MATSUOKA, R.: "THE EXPRESSION OF THE CARDIAC MYOSIN HEAVY-CHAIN GENE." JPN.CIRC.J.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] IMAMURA, S.: "LOCAL RESPONSE TO CARDIAC OVERLOAD ON MYOSIN HEAVY CHAIN GENE EXPRESSION AND ISOZYME TRANSTITION." JPN.CIRC.J.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MATSUOKA, R.: "LOCAL RESPONSE TO CARDIAC OVERLOAD ON MYOSIN HEAVY CHAIN GENE EXPRESSION AND ISOZYME TRANSITION." REPORT FOR THE JAPANESE RESEARCH PROMOTION SOCIETY FOR CADIOVASCULAR DISEASE.

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      「研究成果報告書概要(欧文)」より
  • [Publications] IZUMO, S.: "MYOSIN HEAVY CHAIN mRNA AND PROTEIN ISOFORM TRANSITION DURING CARDIAC HYPERTROPHY." J.CLIN.INVEST.79. 970-977 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MATSUOKA, R.: "THE EFFECT OF CAFFEIN, THEOPHYLLINE AND CYCLIC AMP ON THE EXPRESSION OF THE CARDIAC MYOSIN HEAVY-CHAIN GENE." REPORT FOR THE JAPAN RESEARCH PROMOTION SOCIETY FOR CARDIOVASCULURE DISEASES.20-23 (1987)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MATSUOKA, R.: DEVELOPMENT OF CARDIAC MUSCLE -MYOSIN HEAVY CHAIN GENE :IN: HEART DISEASES IN CHILDHOOD.CHUGAI-IGAKUSHA,

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] IMAMURA, S.: ADAPTATIONAL CHANGES OF MYOSIN HEAVY CHAIN GENE EXPRESSIONS AND ISOZYME TRANSITIONS IN: CARDIAC OVERLOADING. IN: ETIOLOGY AND MORPHOGENESIS OF CONGENITAL HEART DISEASE.FUTURA.,

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MATSUOKA, R.: CARDIAC MYOSIN HEAVY-CHAIN GENE. IN: SHO-NIIGAKU.IGAKU-SHOIN, 18 (1987)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1990-03-20  

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